Deficiency of lubricating surfactant lining the articular surfaces of replaced hips and knees.
Deficiency of lubricating surfactant lining the articular surfaces of replaced hips and knees.
复制标题
置换后的臀部和膝盖的关节表面缺乏润滑表面活性剂。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
M. K. Monds
中科院分区：
文献类型：
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作者：
B. Hills;M. K. Monds
虽然之前的论文已经证明，关节润滑的边界模式中的活性承重剂是表面活性磷脂（SAPL）-可能吸附在关节软骨的最外层-这项研究旨在确定该层是否缺乏骨关节炎（OA）。该层已在12个髋关节和31个膝关节上进行了研究，这些髋关节和膝关节是从患有OA的手术置换关节中获得的。由盐水液滴对着的接触角（θ）的测量清楚地表明疏水性的高度显著降低，θ从13只牛对照的100度（5个人对照的78度）下降到关节炎髋关节的56度，以及关节炎膝关节的“磨损”和“未磨损”区域的63度和68度。这些变化反映在通过溶剂冲洗从相同关节面回收的SAPL（和蛋白脂质）的量上，SAPL的产量在髋关节中低36%，在膝关节的“磨损”区域中低25%，但在“未磨损”区域中无显著差异。这些结果表明，从SF沉积到关节软骨上的SAPL的最外层润滑层在OA中是缺乏的。
While preceding papers have demonstrated that the active load-bearing agent in the boundary mode of joint lubrication is surface-active phospholipid (SAPL)--probably adsorbed as the outermost layer of articular cartilage--this study is designed to determine whether that layer is deficient in osteoarthritis (OA). This layer has been studied on 12 hips and 31 knees obtained from surgically replaced joints afflicted with OA. Measurement of the contact angle (theta) subtended by a droplet of saline clearly demonstrated a highly significant decrease in hydrophobicity, theta falling from 100 degrees for 13 bovine controls (78 degrees for five human controls) to 56 degrees for arthritic hips and 63 degrees and 68 degrees for the 'worn' and 'unworn' areas of arthritic knees, respectively. These changes were reflected in the quantities of SAPL (and proteolipid) recovered from the same articular surfaces by solvent rinsing, yields of SAPL being 36% lower in hips and 25% lower in 'worn' areas of knees, but not significantly different in 'unworn' areas. These results indicate that the outermost lubricating layer of SAPL deposited onto articular cartilage from SF is deficient in OA.