Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients
Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients
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DOI：
10.1093/annonc/mdq212
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发表时间：
2010-10-01
影响因子：
50.5
通讯作者：
Yang, P.
中科院分区：
文献类型：
--
作者：
Sun, Z.;Chen, J.;Yang, P.
Patients and methods: Blood DNA from 248 patients with primary SCLC was genotyped for 419 tag SNPs from 49 genes in the glutathione and DNA repair pathways. Association analyses with patient survival were carried out at single-SNP, whole-gene, and haplotype levels after adjusting for age, gender, tumor stage, treatment modalities, and smoking history.Results: Among the 375 SNPs successfully genotyped, 21 SNPs, located on 11 genes, showed significant association with survival. Whole-gene analyses confirmed 3 of the 11 genes: GSS, ABCC2, and XRCC1. Haplotype analyses of these three genes identified haplotype combinations and genomic locations underlying the observed SNP associations.Conclusion: Genetic variations in genes involved in the glutathione and DNA repair pathways are associated with SCLC survival.
