Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors.
Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors.
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大鼠的循环行为和 [14C]2-脱氧葡萄糖图谱：对自闭症重复行为的可能影响。
DOI：
10.1016/j.nbd.2004.10.012
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发表时间：
2005
影响因子：
6.1
通讯作者：
Moshe,SolomonL
中科院分区：
文献类型：
--
作者：
Velisek,Libor;Veliskova,Jana;Ravizza,Teresa;Giorgi,FilippoS;Moshe,SolomonL
重复性行为（如绕圈）是自闭症的一个定义特征。黑质（SN）参与盘旋。我们使用单侧SN网状部（SNR）注入GABA激动剂蝇蕈醇，以诱导成年和出生后第15天（PN）的雄性和雌性大鼠的盘旋和脱氧葡萄糖放射自显影映射，以确定其底物。在成年人中，蝇蕈醇输注后SNR诱导更高的盘旋率比前SNR，之后男性显示更快的盘旋比女性。相比之下，PN15雌性大鼠比PN15雄性大鼠盘旋得更快。放射自显影显示，与最高的回旋率相关的SN旁丘脑（SNC）脱氧葡萄糖摄取的年龄和性别特异性改变。这些数据表明，有一个密切的关系，GABA能SNR和多巴胺能SNC在诱导盘旋，有一个地形组织的SNR盘旋行为和相关的脱氧葡萄糖摄取，这是依赖于年龄和性别。
Repetitive behaviors (such as circling) are one of the defining features of autism. The substantia nigra (SN) is involved in circling. We used unilateral SN pars reticulata (SNR) infusions of the GABA agonist muscimol to induce circling and deoxyglucose autoradiography mapping in adult and postnatal day (PN) 15 male and female rats to determine its substrates. In adults, muscimol infusions in posterior SNR induced a higher circling rate than in anterior SNR, after which males displayed faster circling than females. In contrast, PN15 female rats circled faster than PN15 male rats. Autoradiograms demonstrated age- and sex-specific alterations of deoxyglucose uptake in the SN pars compacta (SNC) associated with highest circling rates. The data suggest that there is a close relationship of the GABAergic SNR and dopaminergic SNC in the induction of circling; there is a topographic organization of the SNR in terms of circling behavior and associated deoxyglucose uptake, which is dependent on age and sex.