Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.
Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.
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DOI：
10.1146/annurev-bioeng-071114-040723
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发表时间：
2015
影响因子：
9.7
通讯作者：
Kinahan P
中科院分区：
文献类型：
--
作者：
Vaquero JJ;Kinahan P
正电子发射断层扫描（PET）成像是基于从正电子发射放射性同位素的发射中检测两个时间重合的高能光子。发射的物理特性和对重合光子的检测赋予PET成像独特的能力，用于非常高的灵敏度和对放射性示踪剂的体内浓度的准确估计。PET成像已被广泛采用作为肿瘤学、心血管和神经学应用的重要临床模式。PET成像也已成为临床前研究的重要工具，特别是用于研究小鼠疾病模型和其他小动物模型。然而，使用PET成像系统存在若干挑战。这些包括分辨率和噪声之间的基本权衡，测量的定量准确性，以及与X射线计算机断层扫描和磁共振成像的集成。在本文中，我们回顾了研究人员和行业如何应对这些挑战。
Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.