The endocrine transition around menopause -: a five years prospective study with profiles of gonadotropines, estrogens, androgens and SHBG among healthy women
The endocrine transition around menopause -: a five years prospective study with profiles of gonadotropines, estrogens, androgens and SHBG among healthy women
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DOI：
10.1034/j.1600-0412.1999.780714.x
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发表时间：
1999-08-01
影响因子：
4.3
通讯作者：
Holte, A
中科院分区：
文献类型：
--
作者：
Overlie, I;Moen, MH;Holte, A
Objective.本研究的目的是调查在非临床人群绝经过渡期的激素变化。59名健康的挪威妇女参加了一项为期5年的前瞻性纵向研究，从绝经前到绝经后的过渡期，从绝经前1年到4年开始，到绝经后1年到4年结束。这些妇女都没有接受激素替代疗法（HRT）。每12个月采集一次血标本，检测促黄体生成素（LH）、促卵泡激素（FSH）、类固醇激素结合球蛋白（SHBG）、催乳素（PRL）、雌二醇（E-2）、雌酮（El）、睾酮、雄烯二酮、硫酸脱氢表雄烯二酮（DHEA-S）和促甲状腺激素（TSH）。FSH和LH的血清水平，E2和E1谱基本上证实了以前的数据中获得的横断面研究。在绝经前和绝经后两年，所有妇女的血清FSH和LH持续升高，E-2和Fl随之下降。巴斯雄烯二酮和睾酮在绝经前三年呈下降趋势。然而，绝经后，睾丸激素水平出现波动。雄烯二酮与绝经后E2、E1和睾酮均呈正相关。体重指数（BMI）与睾酮相关，但与雄烯二酮无关。BMI与SHBG呈负相关。BMI与E-2、EI、FSH、LH无相关性。这项关于绝经前到绝经后过渡期内激素变化的纵向前瞻性研究表明，不仅雌激素激素变化，而且雄激素变化也在绝经前几年发生。
Objective. The purpose of this study was to investigate the hormonal changes during the menopausal transition in a non-clinical population.Methods. Fifty-nine healthy Norwegian women participated in a five year prospective longitudinal study during the transition from pre- to post-menopause, starting one to four years before menopause, and ending one to four years postmenopausal. None of these women were given hormone replacement therapy (HRT). Blood samples were collected every 12 months and luteinizing hormone (LH), follicle stimulating hormone (FSH), steroid hormone binding globuline (SHBG), prolactin (PRL), estradiol (E-2), estrone (El), testosterone, androstendione, dehydroepiandrostendione-sulphate (DHEA-S), and thyroid stimulating hormone (TSH) were analyzed.Results. The serum levels of FSH and LH, E2 and El profile essentially confirmed previous data obtained in cross-sectional studies. A continuous increase in serum FSH and LH and a concomitant fall in E-2 and Fl were observed in all women before menopause and in the two postmenopausal years:. Bath androstendione and testosterone showed a decline three years before menopause. After the menopause, however, there were fluctuations in the testosterone levels. Androstendione correlated positively with both E-2, and El and testosterone postmenopausally. Body mass index (BMI) did correlate with testosterone, but not with androstendione. BMI correlated negatively with SHBG. No correlation was found between BMI and E-2, EI, FSH and LH.Conclusion. This longitudinal prospective study of hormonal changes during the transition from pre- to postmenopause indicates that not only estrogen hormonal changes, but androgen hormonal changes as well, precedes the menopause by several years.