Plant polyphenols: are they the new magic bullet?
Plant polyphenols: are they the new magic bullet?
复制标题
DOI：
10.1079/pns2003275
复制
发表时间：
2003-08-01
影响因子：
7
通讯作者：
Kyle, JAM
中科院分区：
文献类型：
--
作者：
Duthie, GG;Gardner, PT;Kyle, JAM
流行病学证据表明，富含水果和蔬菜的饮食可以降低因主要临床疾病（包括癌症和心脏病）过早死亡的风险。然而，目前尚不清楚水果和蔬菜中哪些成分或成分组合具有保护作用以及它们的作用机制是什么。这种科学上的不确定性似乎并没有抑制大量植物性混合物的营销，这些混合物被宣传为实现最佳健康的“灵丹妙药”。例如，植物多酚所声称的保健特性代表了热情的营销主张可能远远超过当前科学证据的情况。即使存在良好的实验证据，也需要谨慎解释与人类健康益处相关的结果，因为多酚的生物利用度可能有限，并且也可能被广泛代谢。此外，某些多酚在某些细胞培养系统中可能具有毒性和致突变性。在更多地了解体内多酚的活性和代谢命运之前，消费者最好增加水果和蔬菜的摄入量，并对这些化合物是健康灵丹妙药的说法保持警惕。
Epidemiological evidence suggests that diets rich in fruit and vegetables decrease the risk of premature mortality from major clinical conditions, including cancer and heart disease. However, it is not yet clear which components or combination of components in fruit and vegetables are protective and what is their mechanism of action. Such scientific uncertainty does not seem to inhibit the marketing of a huge range of plant-based concoctions, promoted as 'magic bullets' for optimum health. For example, the purported health-giving properties of plant polyphenols represent a case in which enthusiastic marketing claims may far exceed the current scientific evidence. Even when good experimental evidence exists, results need to be interpreted with caution in relation to human health benefits, as polyphenols may have limited bioavailability and may also be extensively metabolised. In addition, some polyphenols can be toxic and mutagenic in some cell culture systems. Until more is known about the activity and metabolic fate of polyphenols in the body, it would be better for the consumer to increase fruit and vegetable intake, and also to be wary of claims that these compounds are a panacea for good health.