Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recovery
Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recovery
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DOI：
10.1016/j.freeradbiomed.2007.10.040
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发表时间：
2008-02-15
影响因子：
7.4
通讯作者：
Nilakantan, Vani
中科院分区：
文献类型：
--
作者：
Maenpaa, Cheryl J.;Shames, Brian D.;Nilakantan, Vani
Oxidant-mediated apoptosis has been implicated in renal injury due to ischemia reperfusion (IR); however, the apoptotic signaling pathways following IR have been incompletely defined. The purpose of this study was to examine the role of oxidants on cell death in a model of in vitro simulated IR injury in renal proximal tubular epithelial cells by analyzing the effects of a cell-permeable superoxide dismutase mimetic, manganese (111) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride (MnTmPyP). Renal proximal tubular epithelial cells were ATP depleted for 2, 4, or 6 h, followed by 2 h of recovery. We found that MnTmPyP was effective in attenuating cytotoxicity (P
