Characterization of sepik and entebbe bat viruses closely related to yellow fever virus
Characterization of sepik and entebbe bat viruses closely related to yellow fever virus
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DOI：
10.4269/ajtmh.2006.75.1165
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发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Chang, Gwong-Jen J.
中科院分区：
文献类型：
--
作者：
Kuno, Goro;Chang, Gwong-Jen J.
黄热病病毒作为第一个分离的动物病毒和作为黄病毒属的原型病毒，在医学史上具有特殊的地位，其中包含许多严重的人类病原体。直到最近，才在遗传学上确定了该组中与其密切相关的病毒。在这项研究中，我们获得了与黄热病病毒最密切相关的两种病毒的完整或接近完整的基因组序列：巴布亚新几内亚的塞皮克病毒和非洲的恩德培蝙蝠病毒。基于全基因组特征和相关病毒的基因组特征，我们将Sepik病毒鉴定为与黄热病病毒关系最密切的病毒，并分析了黄热病病毒簇成员3 '非编码区的重复序列和保守序列模式。我们还讨论了地理扩散的一部分，这支黄病毒的生态特征。
Yellow fever virus has a special place in medical history as the first animal virus isolated and as the prototype virus in the genus Flavivirus, which contains many serious human pathogens. Only recently, its closely related viruses within the group were identified phylogenetically. In this study, we obtained complete or near complete genome sequences of two viruses most closely related to yellow fever virus: Sepik virus of Papua New Guinea and Entebbe bat virus of Africa. Based on full-genomic characterization and genomic traits among related viruses, we identified Sepik virus to be most closely related to yellow fever virus and analyzed the pattern of repeat and conserved sequence motifs in the 3'-noncoding region among the members of yellow fever virus cluster. We also discuss the geographic dispersal as a part of ecological traits of this lineage of flaviviruses.