Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage.
Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage.
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DOI：
10.1152/ajpendo.00406.2017
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发表时间：
2018-08
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影响因子：
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通讯作者：
C. Price;D. Argueta;V. Medici;A. Bremer;Vivien Lee;Marinelle V. Nuñez;Guoxia X. Chen;N. Keim;P. Havel;K. Stanhope;N. DiPatrizio
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作者：
C. Price;D. Argueta;V. Medici;A. Bremer;Vivien Lee;Marinelle V. Nuñez;Guoxia X. Chen;N. Keim;P. Havel;K. Stanhope;N. DiPatrizio
流行病学和临床研究提供了充分的证据证明，含糖饮料的消费增加了肥胖、2型糖尿病和心血管疾病（CVD）发展的风险因素。我们以前的研究表明，与阿斯巴甜（Asp）相比，2周的高果糖玉米糖浆（HFCS）加糖饮料提供25%的每日能量需求与体重增加，餐后（pp）甘油三酯（TG），空腹和pp CVD风险因素在年轻人。脂肪酸乙醇酰胺（anandamide，AEA）和单酰基甘油（monoacylglycerol，2-arachidonoyl-sn-glycerol，2-AG）是两种主要的内源性大麻素（endocannabinoids，EC），其在调节食物摄入、增加脂肪储存和调节脂质代谢中起作用。因此，我们测量了EC及其类似物，油酰乙醇酰胺（OEA），二十二碳六烯酰乙醇酰胺（DHEA）和二十二碳六烯酰甘油（DHG）的血浆浓度，在我们以前的研究中，这些参与者饮用HFCS-或Asp-sweetened饮料，以确定体重增加和CVD风险因素的相关性。两周暴露于HFCS或Asp-sweetened饮料导致测试期后组间OEA和DHEA空腹水平变化的显着差异。服用天冬氨酸但不服用HFCS的受试者在试验期后显示AEA、OEA和DHEA减少。与此相反，有显着的正相关关系AEA，OEA，和DHEA与ppTG，ppApoCIII，和ppApoE在那些消费HFCS，但不是在那些消费Asp。我们的研究结果揭示了循环内皮细胞和内皮细胞相关分子与脂代谢标志物和HFCS消费后CVD风险之间的先前未知的关联。
Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl- sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS- or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS- or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.