Impact of blood rheology on wall shear stress in a model of the middle cerebral artery
Impact of blood rheology on wall shear stress in a model of the middle cerebral artery
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DOI：
10.1098/rsfs.2012.0094
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发表时间：
2013-04-06
期刊：
影响因子：
4.4
通讯作者：
Coveney, Peter V.
中科院分区：
文献类型：
--
作者：
Bernabeu, Miguel O.;Nash, Rupert W.;Coveney, Peter V.
血液对内皮层施加的机械力的稳态分布的扰动与血管病变有关，包括颅内动脉瘤和动脉粥样硬化。最近的计算工作表明，为了正确地表征这种力，必须考虑血液的剪切变薄特性。据我们所知，这些发现从未与实验观察到的病理阈值进行过比较。在这项工作中，我们采用了Gizzi等人（Gizzi et al. 2011）的三带图（TBD）分析。（Gizzi et al. 2011）三带分解分析脉动流中的壁面剪切应力。理论物理。Rev. E 83,031902。（doi: 10.1103/PhysRevE.83.031902）))评估血液流变学模型的选择对大脑右中动脉计算模型的影响。我们的研究结果表明，在所研究的模型中，牛顿模型和著名的carau - yasuda广义牛顿模型预测的壁面剪切应力之间的差异只有在所研究的血管病理与0.94-1.56 Pa范围内的病理阈值相关时才有意义，而在这种情况下，所考虑的流变模型的TBD分析结果不同。除此之外，我们没有观察到显著差异。
Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies, including intracranial aneurysms and atherosclerosis. Recent computational work suggests that, in order to correctly characterize such forces, the shear-thinning properties of blood must be taken into account. To the best of our knowledge, these findings have never been comparedagainst experimentally observed pathological thresholds. In thiswork, we apply the three-band diagram (TBD) analysis due to Gizzi et al. (Gizzi et al. 2011 Three-band decomposition analysis of wall shear stress in pulsatile flows. Phys. Rev. E 83, 031902. (doi: 10.1103/PhysRevE.83.031902)) to assess the impact of the choice of blood rheology model on acomputational model of the right middle cerebral artery. Our results showthat, in themodel under study, the differences between thewall shear stress predicted by a Newtonian model and thewell-known Carreau-Yasuda generalized Newtonian model are only significant if the vascular pathology under study is associated with a pathological threshold in the range 0.94-1.56 Pa, where the results of the TBD analysis of the rheology models considered differs. Otherwise, we observe no significant differences.