Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.
Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.
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DOI：
10.1097/ypg.0b013e32801118bc
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发表时间：
2007-02
影响因子：
0.9
通讯作者：
Y. Kobayashi;J. Akiyoshi;Masayuki Kanehisa;Shugo Ichioka;Yoshihiro Tanaka;Jusen Tsuru;Hiroaki Hanada;K. Kodama;K. Isogawa;T. Tsutsumi
中科院分区：
文献类型：
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作者：
Y. Kobayashi;J. Akiyoshi;Masayuki Kanehisa;Shugo Ichioka;Yoshihiro Tanaka;Jusen Tsuru;Hiroaki Hanada;K. Kodama;K. Isogawa;T. Tsutsumi
一些报告表明 mGluR 活性与焦虑有关（Tatarczynska 等，2001）。 g-氨基丁酸 A a-6 受体（GABRA6）基因中的 T1521C 多态性与心理压力的激素反应显着减弱有关（Uhart 等，2004）。据报道，在大鼠实验中，阿片受体样蛋白（ORL1）及其内源性肽配体伤害感受肽与焦虑有关（Jenck et al., 2000）。
Some reports suggest that mGluR activity is related to anxiety (Tatarczynska et al., 2001). The T1521C polymorphism in the g-aminobutyric acid A a-6 receptor (GABRA6) gene is associated with markedly attenuated hormonal response to psychological stress (Uhart et al., 2004). It has been reported that opioid-receptor-like protein (ORL1) and its endogenous peptide ligand nociceptin is related to anxiety in rat experiments (Jenck et al., 2000).