PICK'S DISEASE
PICK'S DISEASE
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DOI：
10.1007/978-1-4614-0653-2_23
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Yokota, Osamu
中科院分区：
文献类型：
--
作者：
Takeda, Naoya;Kishimoto, Yuki;Yokota, Osamu
Picks病是一种以额颞叶局限性萎缩为主要临床病理特征的疾病。患有额颞叶萎缩的痴呆患者现在被临床诊断为额颞叶变性（FTLD）。FTLD患者的其他潜在病理包括FTLD伴TDP-43阳性包涵体、皮质基底节变性、进行性核上性麻痹、嗜碱性包涵体病、神经元中间丝包涵体病和嗜银颗粒病。最近的研究结果，关于这些病理性疾病实体的独特的临床和组织病理学特征，包括对未来的死前可能性的讨论诊断患者的疾病。
Picks disease is a major clinicopathological disease having circumscribed atrophy in the frontotemporal lobe. Demented patients with frontotemporal atrophy are now clinically diagnosed as frontotemporal lobar degeneration (FTLD). Other underlying pathologies in patients with FTLD include FTLD with TDP-43-positive inclusions, corticobasal degeneration, progressive supranuclear palsy, basophilic inclusion body disease, neuronal intermediate filament inclusion disease and argyrophilic grain disease.In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.