Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic wave
Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic wave
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DOI：
10.1016/j.jinf.2012.07.004
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发表时间：
2012-11-01
影响因子：
28.2
通讯作者：
Cordero, E.
中科院分区：
文献类型：
--
作者：
Gutierrez-Pizarraya, A.;Perez-Romero, P.;Cordero, E.
目的：在上次大流行之后，关于甲型流感感染的知识有所提高，然而，对B型流感感染的结果的研究仍然很少。本研究的目的是比较流感B与流感A（H1N1）pdm 09感染的特点在2010-2011年流感季节。方法：一个前瞻性，观察队列的成年人实验室确诊的流感感染在2010-2011年流感季节进行了研究结果：50例流感B和80例流感A（H1N1）pdm 09感染。在B型流感患者中，中位年龄为34岁（23-64岁），30%妊娠，24%肥胖，34%接受移植，14%合并细菌感染。28%的患者有肺泡局限性肺炎，5例（10%）死亡。肺炎与延迟抗病毒治疗、年龄较大、Charlson评分较高、有创机械通气和细菌合并感染相关。肥胖和妊娠与并发B型流感感染无关。甲型H1N1流感pdm 09和B型流感感染病例的肺炎比例、入住ICU的比例和死亡率无差异。结论：甲型H1N1流感pdm 09感染与B型流感感染相似，可导致严重感染，并与肺炎或死亡相关。在流行期间，快速诊断和早期抗病毒治疗对于管理流感肺炎是必要的。(C)2012年，英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: After the last pandemic the knowledge regarding influenza A infection has improved however, the outcomes of influenza B infection remain poorly studied. The aim of this study was to compare the features of influenza B versus influenza A(H1N1)pdm09 infections during the 2010-2011 epidemic-season.Methods: A prospective, observational-cohort of adults with laboratory-confirmed influenza infection during the 2010-2011 epidemic-season was studiedResults: Fifty cases of influenza B and 80 of influenza A(H1N1) pdm09 infection were enrolled. Among patients with influenza B, the median age was 34 years-old (23-64), 30% pregnant, 24% obese, 34% transplant recipients and 14% with bacterial co-infection. Twenty-eight percent of patients had pneumonia with alveolar localized pattern and five (10%) died. Pneumonia was associated with delayed antiviral therapy, older age, higher Charlson score, invasive mechanical ventilation and bacterial co-infection. Obesity and pregnancy were not associated with complicated influenza B infection. The proportion of pneumonia, admission to the ICU and mortality did not differ between cases of influenza A(H1N1) pdm09 and influenza B infection.Conclusions: Influenza B infection causes severe infection and it is associated with pneumonia or death, similar to influenza A(H1N1) pdm09 infection. Rapid diagnosis and early antiviral therapy are necessary for managing influenza pneumonia during epidemic periods. (C) 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.