The first applications of carbene ligands in cross-couplings of alkyl electrophiles: Sonogashira reactions of unactivated alkyl bromides and iodides
The first applications of carbene ligands in cross-couplings of alkyl electrophiles: Sonogashira reactions of unactivated alkyl bromides and iodides
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DOI：
10.1021/ja038177r
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发表时间：
2003-11-12
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Eckhardt, M;Fu, GC
Pd/N-杂环卡宾基催化剂在温和条件下实现了一系列官能化的含β-氢烷基溴和碘的Sonogashira偶联。通过提供的第一个例子的非膦基钯催化剂的交叉偶联未活化的烷基亲电试剂，这项研究提供了一个动力，在催化剂的发展，延伸超越膦配体的未来努力。
A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, β-hydrogen-containing alkyl bromides and iodides under mild conditions. By furnishing the first example of a nonphosphine-based palladium catalyst for cross-coupling unactivated alkyl electrophiles, this study provides an impetus for future efforts at catalyst development that extend beyond phosphine ligands.