An Automated Method for Characterization of Evoked Single-Trial Local Field Potentials Recorded from Rat Barrel Cortex Under Mechanical Whisker Stimulation
An Automated Method for Characterization of Evoked Single-Trial Local Field Potentials Recorded from Rat Barrel Cortex Under Mechanical Whisker Stimulation
复制标题
DOI：
10.1007/s12559-016-9399-3
复制
发表时间：
2016-10-01
影响因子：
5.4
通讯作者：
Vassanelli, Stefano
中科院分区：
文献类型：
--
作者：
Mahmud, Mufti;Cecchetto, Claudia;Vassanelli, Stefano
啮齿动物通过定位物体和非常精确地检测纹理来探索周围环境。在这种触觉探索过程中，触须偏转首先由感受器机械地转导，然后在躯体感觉“桶”皮层结束的整个躯体感觉通路中编码信息。在桶状皮层中，来自单个触须的触觉信息被分离并在与偏转的触须相对应的皮层列中处理。局部场电位（LFPs）产生的晶须偏转在桶皮质呈现典型的签名的形状和幅度，与当地的神经元群体的激活。因此，对这种反应的严格分析可以揭示潜在神经元微电路功能的重要特征。在这种情况下，需要用于表征单次试验LFP的软件方法，该方法也适用于LFP特征的在线提取和脑机接口应用。在这项工作中，我们提出了一个自动化和有效的方法来分析诱发LFP反应在大鼠桶皮层通过自动删除刺激文物，检测单个事件和表征其相关参数。两种不同的麻醉剂下记录的诱发单次试验LFP检查，以证明该方法的可行性，准确性和适用性。
Rodents explore their surroundings through whisking by localizing objects and detecting textures very precisely. During such tactile exploration, whisker deflection is first mechanically transduced by receptors and then information encoded throughout the somatosensory pathway ending in the somatosensory 'barrel' cortex. In the barrel cortex, tactile information from a single whisker is segregated and processed in a cortical column corresponding to the deflected whisker. Local Field Potentials (LFPs) generated by whisker deflection in the barrel cortex present typical signatures in terms of shape and amplitude that are related to the activation of the local neuronal populations. Therefore, rigorous analysis of such responses may reveal important features about the function of underlying neuronal microcircuits. In this context, software methods for characterizing single-trial LFPs are needed that are also suitable for online extraction of LFP features and for brain-machine interfacing applications. In this work, we present an automated and efficient method to analyze evoked LFP responses in the rat barrel cortex through automatic removal of stimulation artifacts, detection of single events and characterization of their relevant parameters. Evoked single-trial LFPs recorded under two different anesthetics are examined to demonstrate the feasibility, accuracy and applicability of the method.