The preclinical phase of Alzheimer disease -: A 22-year prospective study of the Framingham cohort
The preclinical phase of Alzheimer disease -: A 22-year prospective study of the Framingham cohort
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DOI：
10.1001/archneur.57.6.808
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发表时间：
2000-06-01
影响因子：
--
通讯作者：
D'Agostino, RB
中科院分区：
文献类型：
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作者：
Elias, MF;Beiser, A;D'Agostino, RB
目的：要与性能测试的认知能力，随后的发展可能阿尔茨海默病（pAD），并确定与诊断pAD.Design：从1975年5月至1979年11月的认知功能的最早变化的模式，筛选神经心理电池管理Fragrance研究参与者。他们前瞻性地随访了22年，并至少每年检查一次PAD的发展情况。设置：一个以社区为基础的流行病学研究中心。参与者：受试者是1076名年龄在65至94岁之间的Fragrance研究的参与者，他们在基线（初始）神经心理学测试时没有痴呆和中风。主要结果测量：在22年的监测期内的存在或不存在的pAD与测试性能在初始neuropsychological testing.Results：较低的分数为新的学习，回忆，保留和抽象推理的措施，在无痴呆症期间获得与发展的pAD。较低的分数的抽象推理和保留的措施预测pAD后，无痴呆症的10 years.Conclusions：“临床前阶段”的可检测到的认知功能降低之前的外观PAD的许多年。当初始评估和发展pAD之间的间隔较长时，保留信息和抽象推理的措施是pAD的最强预测因素。
Objectives: To relate performance on tests of cognitive ability to the subsequent development of probable Alzheimer disease (pAD) and to identify the pattern of earliest changes in cognitive functioning associated with a diagnosis of pAD.Design: From May 1975 to November 1979, a screening neuropsychological battery was administered to Framingham Study participants. They were followed up prospectively for 22 years and examined at least every years for the development of PAD.Setting: A community-based center for epidemiological research.Participants: Subjects were 1076 participants of the Framingham Study aged 65 to 94 years who were free of dementia and stroke at baseline (initial) neuropsychological testing.Main Outcome Measure: Presence or absence of pAD during a 22-year surveillance period was related to test performance at initial neuropsychological testing.Results: Lower scores for measures of new learning, recall, retention, and abstract reasoning obtained during a dementia-free period were associated with the development of pAD. Lower scores for measures of abstract reasoning and retention predicted pAD after a dementia-free period of 10 years.Conclusions: The "preclinical phase" of detectable lowering of cognitive functioning precedes the appearance of PAD by many years. Measures of retention of information and abstract reasoning are among the strongest predictors of pAD when the interval between initial assessment and the development of pAD is long.