RNA conformational classes
RNA conformational classes
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DOI：
10.1093/nar/gkh333
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发表时间：
2004-03-01
影响因子：
14.9
通讯作者：
Berman, HM
中科院分区：
文献类型：
--
作者：
Schneider, B;Morávek, Z;Berman, HM
RNA的构象具有很大的多样性。从一个大的核糖体亚基的结构中分析了3000个核苷酸，以确定它们的构象。在该数据集上对扭角的六个3D分布进行傅立叶平均，并对所得的伪电子图进行分析，然后对扭角的优选组合进行聚类。发现了18个非A型构象和14个与A-RNA相关的构象，并测定了它们的扭转角，得到了它们的笛卡尔坐标。
RNA exhibits a large diversity of conformations. Three thousand nucleotides of 23S and 5S ribosomal RNA from a structure of the large ribosomal subunit were analyzed in order to classify their conformations. Fourier averaging of the six 3D distributions of torsion angles and analyses of the resulting pseudo electron maps, followed by clustering of the preferred combinations of torsion angles were performed on this dataset. Eighteen non-A-type conformations and 14 A-RNA related conformations were discovered and their torsion angles were determined; their Cartesian coordinates are available.