Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells
Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells
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DOI：
10.1007/s00418-016-1444-5
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发表时间：
2016-08-01
影响因子：
2.3
通讯作者：
Ueno, Masaki
中科院分区：
文献类型：
--
作者：
Murakami, Ryuta;Chiba, Yoichi;Ueno, Masaki
已知高果糖摄入与血浆甘油三酯浓度升高、糖耐量受损、胰岛素抵抗和高血压有关。此外，过量果糖摄入也被认为是痴呆症的危险因素。先前的免疫组织化学研究表明，人类、大鼠和小鼠大脑的脉络丛上皮细胞和室管膜细胞中存在果糖的主要转运蛋白葡萄糖转运蛋白5（GLUT5），而果糖的次要转运蛋白GLUT2则位于大鼠大脑的室管膜细胞中。在这项研究中，在人和小鼠的脉络丛上皮细胞和室管膜细胞的细胞质中观察到果糖转运蛋白 GLUT8 的免疫反应性。这些结构对 GLUT7、GLUT11 和 GLUT12 没有免疫反应性。我们的研究结果支持血管内果糖通过脉络丛上皮细胞和室管膜细胞转运的假设。
High fructose intake is known to be associated with increased plasma triglyceride concentration, impaired glucose tolerance, insulin resistance, and high blood pressure. In addition, excess fructose intake is also thought to be a risk factor for dementia. Previous immunohistochemical studies have shown the presence of glucose transporter 5 (GLUT5), a major transporter of fructose, in the epithelial cells of the choroid plexus and ependymal cells in the brains of humans, rats, and mice, while GLUT2, a minor transporter of fructose, was localized in the ependymal cells of rat brain. In this study, immunoreactivity for the fructose transporter GLUT8 was observed in the cytoplasm of the epithelial cells in the choroid plexus and in the ependymal cells of the brains of humans and mice. These structures were not immunoreactive for GLUT7, GLUT11, and GLUT12. Our findings support the hypothesis of the transport of intravascular fructose through the epithelial cells of the choroid plexus and the ependymal cells.