Aberrant cytokine secretion and zinc uptake in chronic cadmium‐exposed lung epithelial cells
Aberrant cytokine secretion and zinc uptake in chronic cadmium‐exposed lung epithelial cells
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DOI：
10.1002/prca.201600059
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Yan-Ming Xu;Yangmin Gao;Dan-Dan Wu-Dan;Feiyuan Yu;Zhong-Sheng Zang;Lei Yang;Yue Yao;Na-Li Cai;Yuan Zhou;J. Chiu;Y. Ching;Andy T. Y. Lau
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文献类型：
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作者：
Yan-Ming Xu;Yangmin Gao;Dan-Dan Wu-Dan;Feiyuan Yu;Zhong-Sheng Zang;Lei Yang;Yue Yao;Na-Li Cai;Yuan Zhou;J. Chiu;Y. Ching;Andy T. Y. Lau
我们之前的研究结果表明，镉（Cd）适应的肺上皮细胞（LEC）由于c-Jun N-末端激酶途径的非反应性和细胞角蛋白8的表达增强而对凋亡产生抗性。由于细胞内镉进入是镉引起其细胞毒性的先决条件，因此，我们想知道是否有差异的金属离子转运能力和其他表型变化，发生在这些镉抗性LEC。
Our previous results showed that cadmium (Cd)‐adapted lung epithelial cells (LECs) developed resistance to apoptosis due to non‐responsiveness of the c‐Jun N‐terminal kinase pathway and augmented expression of cytokeratin 8. Since cellular Cd entry is a prerequisite in order for Cd to elicit its cytotoxicity, therefore, we wonder if there are differential metal ion transport ability and also other phenotypic changes that occurred in these Cd‐resistant LECs.