Metastatic breast cancer from gastric and ovarian cancer, mimicking inflammatory breast cancer: report of two cases
Metastatic breast cancer from gastric and ovarian cancer, mimicking inflammatory breast cancer: report of two cases
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DOI：
10.1007/s12282-008-0040-5
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发表时间：
2008-10-01
期刊：
影响因子：
4
通讯作者：
Sekiya, Masao
中科院分区：
文献类型：
--
作者：
Sato, Tomoi;Muto, Ichiro;Sekiya, Masao
乳腺外恶性肿瘤的乳腺转移，特别是那些模仿原发性炎性乳腺癌，是非常罕见的。我们在此报告两例胃癌或卵巢癌炎性乳腺转移。这两名患者都有晚期恶性肿瘤病史，表现为单侧乳房红肿伴橙色斑征，类似于原发性炎性乳腺癌或急性乳腺炎。乳腺活检显示低分化腺癌与印戒细胞或透明细胞癌的淋巴管和实质没有原位病变，类似于胃或卵巢的原发性病变，分别。雌激素受体、孕激素受体和大体囊性病液蛋白15的免疫组化染色对正确诊断有价值。由于乳腺转移是原发恶性肿瘤预后不良的标志，因此在适当的患者中应考虑乳腺转移的可能性，以避免不必要的大手术。
Breast metastases from extra-mammary malignancies, especially those mimicking primary inflammatory breast carcinoma, are extremely rare. We report here two cases of inflammatory breast metastases from gastric or ovarian cancer. Both patients, who had prior advanced malignant disease, presented with unilateral breast redness and swelling with peau d'orange sign, resembling primary inflammatory breast cancer or acute mastitis. Breast biopsy revealed poorly differentiated adenocarcinoma with signet-ring cells or clear cell carcinoma in the lymphatic vessels and the parenchyma without an in situ lesion, similar to primary lesions of the stomach or ovary, respectively. Immunohistochemical staining for estrogen receptor, progesterone receptor, and gross cystic disease fluid protein 15 was of value for correct diagnosis. Since breast metastasis is a sign of poor prognosis of the primary malignant disease, the possibility of breast metastasis should be considered in appropriate patients to preclude unnecessary major surgery.