Interstitial Myocardial Fibrosis Assessed as Extracellular Volume Fraction with Low-Radiation-Dose Cardiac CT
Interstitial Myocardial Fibrosis Assessed as Extracellular Volume Fraction with Low-Radiation-Dose Cardiac CT
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DOI：
10.1148/radiol.12112458
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发表时间：
2012-09-01
期刊：
影响因子：
19.7
通讯作者：
Bluemke, David A.
中科院分区：
文献类型：
--
作者：
Nacif, Marcelo Souto;Kawel, Nadine;Bluemke, David A.
目的：开发一种心脏计算机断层扫描（CT）的方法，以确定细胞外容积（ECV）分数，与心脏磁共振（MR）成像作为参考standard.Materials和方法：研究参与者提供书面知情同意书参加本机构审查委员会批准的研究。采用心脏CT和心脏MR成像技术测量健康受试者和心力衰竭患者的ECV。采用配对t检验、线性回归分析和Pearson相关分析确定心脏CT和MR成像ECV值与临床参数之间的关系。心脏MRI测量的心肌ECV与心脏CT测量的心肌ECV具有良好的相关性（r = 0.82，P <0.001）。正如预期，心脏CT和心脏MR成像显示，心力衰竭患者的ECV高于健康对照受试者（分别为P = 0.03）。对于心脏MR成像和心脏CT，ECV与舒张末期和收缩末期容积呈正相关，与射血分数呈负相关（均P <0.05）。平均辐射剂量为1.98 mSv +/- 0.16（标准差）为每个心脏CT acquisition.Conclusion：ECV在心脏CT和心脏MR成像表现出良好的相关性，表明心肌组织定征与心脏CT的潜力。(C)RSNA，2012年
Purpose: To develop a cardiac computed tomographic (CT) method with which to determine extracellular volume (ECV) fraction, with cardiac magnetic resonance (MR) imaging as the reference standard.Materials and Methods: Study participants provided written informed consent to participate in this institutional review board-approved study. ECV was measured in healthy subjects and patients with heart failure by using cardiac CT and cardiac MR imaging. Paired Student t test, linear regression analysis, and Pearson correlation analysis were used to determine the relationship between cardiac CT and MR imaging ECV values and clinical parameters.Results: Twenty-four subjects were studied. There was good correlation between myocardial ECV measured at cardiac MR imaging and that measured at cardiac CT (r = 0.82, P < .001). As expected, ECV was higher in patients with heart failure than in healthy control subjects for both cardiac CT and cardiac MR imaging (P = .03, respectively). For both cardiac MR imaging and cardiac CT, ECV was positively associated with end diastolic and end systolic volume and inversely related to ejection fraction (P < .05 for all). Mean radiation dose was 1.98 mSv +/- 0.16 (standard deviation) for each cardiac CT acquisition.Conclusion: ECV at cardiac CT and that at cardiac MR imaging showed good correlation, suggesting the potential for myocardial tissue characterization with cardiac CT. (C) RSNA, 2012