Delayed and Aberrant Presentation of VX2 Carcinoma in a Rabbit Model of Hepatic Neoplasia.
Delayed and Aberrant Presentation of VX2 Carcinoma in a Rabbit Model of Hepatic Neoplasia.
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DOI：
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发表时间：
2015-10
影响因子：
0.8
通讯作者：
Sarah A. Hansen;Michael K Fink;Anandhi Upendran;C. Besch-Williford;R. Livingston;J. Amos-Landgraf;J. Lattimer;R. Kannan
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文献类型：
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作者：
Sarah A. Hansen;Michael K Fink;Anandhi Upendran;C. Besch-Williford;R. Livingston;J. Amos-Landgraf;J. Lattimer;R. Kannan
作为纳米颗粒研究的一部分，在肝内注射VX2癌细胞悬浮液以诱导肝细胞癌后约11个月，一只社会安置的新西兰大白兔在腹侧胸腔出现一个巨大的皮下肿块。肿块和密切相关的腋窝淋巴结被整块切除。免疫组织化学染色证实肿块为未分化癌。在接种VX2后16个月的研究终点，兔未表现出明显的病理改变。另一只来自同一VX2注射队列的兔子在尸检中被发现有意想不到的腹内肿块，也被确认为未分化癌。这一病例报告总结了通过一种新的聚合酶链式反应方法对两种肿瘤进行的分子分析，该方法鉴定了VX2癌的延迟和异常发病时间，这是以前没有报道过的。
A socially-housed New Zealand white rabbit presented with a large subcutaneous mass on the ventral thorax approximately 11 mo after the intrahepatic delivery of a suspension of VX2 carcinoma cells to induce hepatocellular carcinoma as part of a nanoparticle study. The mass and closely associated axillary lymph node were removed en bloc. Immunohistochemical staining identified the mass as an undifferentiated carcinoma. The rabbit demonstrated no appreciable pathology at the study end point at 16 mo after VX2 inoculation. An additional rabbit from the same VX2 injection cohort was found at necropsy to have an unanticipated intraabdominal mass, also identified as an undifferentiated carcinoma. This case report summarizes the molecular analysis of both tumors through a novel PCR assay, which identified the delayed and aberrant onset of VX2 carcinoma in an extended timeframe not previously reported.