Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
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DOI：
10.1016/s0022-3956(97)00022-8
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发表时间：
1997-11-01
影响因子：
4.8
通讯作者：
Frolich, L
中科院分区：
文献类型：
--
作者：
Maurer, K;Ihl, R;Frolich, L
在与老年相关的精神疾病中，阿尔茨海默型(DAT)的原发性退行性痴呆(DAT)近年来越来越受到重视。尽管目前还不可能对这种疾病进行根治，但可以使用各种药物来减缓其进展。本研究采用双盲、随机、安慰剂对照平行对照设计，对20例门诊患者口服240 mg/d银杏叶特殊提取物银杏叶提取物EGB 761(由卡尔斯鲁厄Willmar Schwabe博士生产的Tebonin(R)Forte)对DAT临床病程的影响进行了研究。疗程均为3个月。主要结果变量是SKT测试中用于确定注意力和记忆力的总分。其他心理测量测试(拖车测验、ADAS、CGI)和电生理检查(脑电地形图)进行描述性评估。尽管积极治疗组的平均总分为19.67分，但S.K.T.的基线水平低于安慰剂组(18.11分)。经银杏叶提取物761治疗后改善至16.78分。而安慰剂组的得分下降到18.89分。基准值和最终值之间的差异构成了统计分组比较的基础，统计分组比较的结果对eGB 761有利，显著水平为p。
Among the psychiatric illnesses associated with old age primary degenerative dementia of the Alzheimer type (DAT) has gained increasing importance in recent years. Even though a curative treatment of the disease is currently impossible, various drugs can be used to slow down its progression. In the present study the influence of oral treatment with 240 mg/day of Ginkgo biloba special extract EGb 761 (Tebonin(R) forte, manufactured by Dr Willmar Schwabe, Karlsruhe) on the clinical course of DAT was investigated in a double-blind, randomized, placebo-controlled parallel-group design in 20 outpatients. The duration of treatment was 3 months. The primary outcome variable was the sum score in the SKT-test for the determination of attention and memory. Other psychometric tests (trailmaking test, ADAS, CGI) and electrophysiological investigations (EEG topography) were evaluated descriptively. Although the active-treatment group, with a mean sum score of 19.67 points in the, S.K.T., had a poorer baseline level than the placebo group (18.11 points). it experienced an improvement to 16.78 points under treatment with EGb 761. whereas the placebo group deteriorated to 18.89 points. The differences between the baseline and final values formed the basis for a statistical group comparison, which gave a result favourable to EGb 761, at a significance level of p