Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion
Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion
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DOI：
10.3174/ajnr.a1247
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Barkovich, A. J.
中科院分区：
文献类型：
--
作者：
Takanashi, J.;Tada, H.;Barkovich, A. J.
急性脑病伴双相癫痫发作和晚期弥散减少（AESD）是最近描述的一种临床放射学综合征。3例AESD患者的MR波谱显示，在发病的一周内，N-乙酰天冬氨酸（NAA）降低，谷氨酰胺/谷氨酸复合物（Glx）升高。之后，Glx恢复正常，而NAA在2例有神经系统后遗症的患者中保持较低水平，但在第3例无神经系统后遗症的患者中几乎恢复正常。这些发现支持了兴奋性神经元损伤在AESD的发病机制中起重要作用的假设，并表明MR波谱可能是预测结果。
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N-acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome.