Molecular pathogenesis of Staphylococcus aureus infection.
Molecular pathogenesis of Staphylococcus aureus infection.
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DOI：
10.1203/pdr.0b013e31819dc44d
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发表时间：
2009-05
影响因子：
3.6
通讯作者：
Liu GY
中科院分区：
文献类型：
--
作者：
Liu GY
金黄色葡萄球菌已经发展出一种全面的策略来应对人类免疫系统带来的挑战。在没有诱发条件的个体中出现社区相关的耐甲氧西林金黄色葡萄球菌（CA-MRSA）感染表明该细菌的致病性增加，这可能与获得新的遗传元件有关。值得注意的是，尽管进行了大量研究，但该流行病的根本原因尚不清楚。在这里，我回顾了金黄色葡萄球菌在定植和感染过程中用来逃避人类宿主设置的障碍的各种策略。我描述了围绕 MRSA 研究的争议，并讨论了新基因的获得如何解释 CA-MRSA 疾病发病率和严重程度的增加。
S. aureus has evolved a comprehensive strategy to address the challenges posed by the human immune system. The emergence of community-associated methicillin-resistant S. aureus (CA-MRSA) infections in individuals with no predisposing conditions suggests an increased pathogenicity of the bacterium, which may be related to acquisition of novel genetic elements. Remarkably, despite an abundance of research, the underlying cause of the epidemic is not known. Here, I review the various strategies used by S. aureus to evade obstacles laid out by the human host during colonization and infection. I describe the controversies surrounding MRSA research and discuss how acquisition of the novel genes could explain the increased incidence and severity of CA-MRSA diseases.