Parasympathetic effects on heart rate recovery after exercise
Parasympathetic effects on heart rate recovery after exercise
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DOI：
10.1136/jim-52-06-34
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发表时间：
2004-09-01
影响因子：
2.6
通讯作者：
Goldberger, JJ
中科院分区：
文献类型：
--
作者：
Kannankeril, PJ;Le, FK;Goldberger, JJ
背景：运动及其恢复期与相对于久坐期的死亡风险增加有关。它们还伴随着自主神经张力的动态变化。关于副交感神经的影响，在高强度的运动和recovery.Methods：10名正常人（5名妇女，年龄33 +/- 2岁）进行了自行车测力计上的运动测试。在第1天，受试者使用分级方案运动至最大耐受工作负荷，最大工作负荷5分钟（峰值心率达到174.7 +/- 5.4 bpm）。第2天，受试者进行与第1天相同的运动方案;进入最大运动阶段1分钟后，给予阿托品（0.04 mg/kg）。运动时每分钟记录一次心率，恢复时每分钟记录一次心电图，持续10分钟。副交感神经对心率的影响通过使用和不使用阿托品时心率的差异来定义。结果：最大运动期间副交感神经的影响为3.4至6 bpm（p <0.05）。在恢复过程中，副交感神经对心率的影响在1分钟内出现（22.8出生; p < .0002），增加到4分钟，然后保持稳定，直到10分钟。尽管副交感神经阻滞后心率加快，但P-R间期缩短（p <0.002），这与恢复期副交感神经对房室结的显著影响一致。在2天的Q-T-R-R关系的评价表现出显着的变化，斜率（p < .0001）和截距（p < .0001），符合修改心室复极的副交感神经张力在recovery.Conclusion：这些数据表明，在正常人中，副交感神经的影响持续高强度的运动，并在恢复的早期阶段是突出的。这些副交感神经效应可能在预防这些风险增加期间的心脏性猝死方面发挥重要作用。
Background: Exercise and its recovery period are associated with increased risk of death relative to sedentary periods. They are also accompanied by dynamic changes in autonomic tone. Little information is available regarding parasympathetic effects during high-intensity exercise and recovery.Methods: Ten normal subjects (five women; age 33 +/- 2 years) underwent exercise testing on a bicycle ergometer. On day 1, subjects exercised to maximum tolerated workload using a graded protocol with 5 minutes at maximal workload (peak heart rate achieved 174.7 +/- 5.4 bpm). On day 2, subjects performed the identical exercise protocol as on day 1; 1 minute into the maximum exercise stage, atropine (0.04 mg/kg) was administered. Heart rate was recorded every minute during exercise, and an electrocardiogram was recorded every minute in recovery for 10 minutes. The parasympathetic effect on heart rate was defined by the difference in heart rate with and without atropine.Results: The parasympathetic effect during maximal exercise was 3.4 to 6 bpm (p < .05). During recovery, a large parasympathetic effect on heart rate was noted by 1 minute (22.8 born; p < .0002), increased until 4 minutes, and then remained stable until 10 minutes. Despite faster heart rates with parasympathetic blockade, the P-R interval was shorter (p < .002), consistent with a significant parasympathetic effect on the atrioventricular node in recovery. Evaluation of the Q-T-R-R relationship on the 2 days demonstrated significant changes in both the slope (p < .0001) and the intercept (p < .0001), consistent with a modification of ventricular repolarization by parasympathetic tone in recovery.Conclusion: These data indicate that in normal subjects, parasympathetic effects persist during high-intensity exercise and are prominent in the early phases of recovery. These parasympathetic effects may play an important role in prevention of sudden cardiac death during these periods of increased risk.