Role of glutamine in immunologic responses
Role of glutamine in immunologic responses
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DOI：
10.1016/s0899-9007(98)00009-4
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发表时间：
1998-07-01
期刊：
影响因子：
4.4
通讯作者：
Shabert, JK
中科院分区：
文献类型：
--
作者：
Wilmore, DW;Shabert, JK
谷氨酰胺传统上被认为是一种非必需氨基酸，但实验室和临床数据表明，在某些炎症情况下，如感染和损伤，谷氨酰胺可能是必不可少的。谷氨酰胺是细胞增殖所必需的营养物质，是炎性细胞和肠道细胞的特定燃料，当存在于适当浓度时，可增强细胞功能。在炎症状态下，谷氨酰胺的消耗可能超过内源性产生，可能存在相对的谷氨酰胺缺乏状态。动物和临床研究表明，通过适当的途径提供适当剂量的这种营养物质，以达到足够的组织浓度，可能会改善结果。这种方法避免了患者暴露在当今常规营养的一些不足之处。为所有代谢受损的患者提供适当的谷氨酰胺补充饮食的总体好处来自于这种氨基酸的多种合成代谢和宿主保护作用，其中免疫调节只是谷氨酰胺基本性质的一个重要方面。营养学1998；14：618-626。(C)Elsevier Science Inc.1998。
Glutamine has traditionally been thought of as a nonessential amino acid, but laboratory and clinical data suggests that it may be essential during certain inflammatory conditions, such as infection and injury. Glutamine is a necessary nutrient for cell proliferation, serves as a specific fuel for inflammatory cells and enterocytes, and, when present in appropriate concentrations, enhances cell function. During inflammatory states, glutamine consumption may outstrip endogenous production and a relative glutamine deficiency state may exist. Animal and clinical studies suggest that improved outcome may be possible by providing the appropriate dose of this nutrient by the appropriate route to achieve adequate tissue concentrations. Such an approach prevents patients from being exposed to some of the inadequacies of present day conventional nutrition. The overall benefit of providing an appropriate glutamine-supplemented diet to all metabolically compromised patients arises from the multiple anabolic and host protective effects of this amino acid, of which immunomodulation is only one important facet of glutamine's essential nature. Nutrition 1998;14:618-626. (C) Elsevier Science Inc. 1998.