Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control.
Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control.
复制标题
颞叶癫痫改变语音控制的听觉运动整合
DOI：
10.1038/srep28909
复制
发表时间：
2016-06-30
影响因子：
4.6
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Li W;Chen Z;Yan N;Jones JA;Guo Z;Huang X;Chen S;Liu P;Liu H
颞叶癫痫(TLE)是成人最常见的药物难治性局灶性癫痫。以前的研究表明，TLE患者在听语音方面表现出下降的表现，在听觉信息的皮质处理方面也存在缺陷。然而，TLE是否会损害语音控制的听觉-运动整合，在很大程度上仍是个未知数。为了解决这个问题，我们比较了28例TLE患者和28例健康对照的事件相关电位(ERPs)和在听觉反馈中听到的音高错误(1/2或2个半音以上)时的发声反应。与健康对照组相比，TLE患者的发声反应显著增加，而P2反应明显减少。此外，TLE患者的发声反应幅度与基线嗓音变异性呈正相关，P2波幅与病程呈负相关。图形网络分析显示，与健康对照组相比，TLE患者的神经网络被破坏，聚集系数和路径长度显著增加。这些发现提供了强有力的证据，表明TLE与听觉和运动系统的非典型整合有关，以进行音调调节，并且支持音调反馈错误的听觉-运动处理的功能网络在TLE患者和健康对照组之间有所不同。
Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.