Which influenza vaccine formulation should be used in Kenya? A comparison of influenza isolates from Kenya to vaccine strains, 2007-2013
Which influenza vaccine formulation should be used in Kenya? A comparison of influenza isolates from Kenya to vaccine strains, 2007-2013
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DOI：
10.1016/j.vaccine.2016.03.095
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发表时间：
2016-05-17
期刊：
影响因子：
5.5
通讯作者：
Katz, Mark A.
中科院分区：
文献类型：
--
作者：
Waiboci, Lilian W.;Mott, Joshua A.;Katz, Mark A.
简介：世界卫生组织(WHO)每年都会建议北半球(NH)和南半球(SH)流感疫苗应包括哪些流感病毒株。为了确定最适合肯尼亚的疫苗配方，我们将2007年4月至2013年5月在肯尼亚收集的流感病毒与WHO疫苗株进行了比较。方法：收集呼吸系统疾病患者的鼻咽和口咽(NP/OP)样本，进行流感检测，从部分阳性样本中分离流感病毒，检测分离株与疫苗株的抗原相关性，并确定流行病毒与SH或NH流感疫苗组成和程序的匹配百分比。结果：在六年中，在收集的60,072份NP/OP标本中，有7.336份(12.2%)对流感呈阳性反应：30,167份标本是在SH季节采集的，3,717份(12.3%)对流感呈阳性；甲型流感2903例(78.1%)，乙型流感902例(24.2%)，甲型和乙型流感阳性88例(2.4%)。我们在NH季节收集了30131份样本，其中3978份(13.2%)流感阳性，3181份(80.0%)甲型流感，851份(21.4%)乙型流感，54份(1.4%)甲型和乙型流感阳性样本。总体而言，来自SH季节的362/460株(78.7%)和NH季节的316/338株(93.5%)分别与SH和NH疫苗株匹配(p<；0.001)。总体而言，53.6%和46.4%的SH和NH疫苗在疫苗毒株和时间上分别与流行毒株匹配。结论：在肯尼亚六年的监测中，流感在SH和NH流感季节的传播水平几乎相同。正在传播的病毒与疫苗株相匹配。当同时考虑疫苗品种和时间时，疫苗匹配率降低。任何一种疫苗配方都可能适合在肯尼亚使用，但需要确定接种流感疫苗的最佳时间。(C)2016爱思唯尔有限公司。保留所有权利。
Introduction: Every year the World Health Organization (WHO) recommends which influenza virus strains should be included in a northern hemisphere (NH) and a southern hemisphere (SH) influenza vaccine. To determine the best vaccine formulation for Kenya, we compared influenza viruses collected in Kenya from April 2007 to May 2013 to WHO vaccine strains.Methods: We collected nasopharyngeal and oropharyngeal (NP/OP) specimens from patients with respiratory illness, tested them for influenza, isolated influenza viruses from a proportion of positive specimens, tested the isolates for antigenic relatedness to vaccine strains, and determined the percentage match between circulating viruses and SH or NH influenza vaccine composition and schedule.Results: During the six years, 7.336 of the 60,072 (12.2%) NP/OP specimens we collected were positive for influenza: 30,167 specimens were collected during the SH seasons and 3717 (12.3%) were positive for influenza; 2903 (78.1%) influenza A, 902 (24.2%) influenza B, and 88 (2.4%) influenza A and B positive specimens. We collected 30,131 specimens during the NH seasons and 3978 (13.2%) were positive for influenza; 3181 (80.0%) influenza A, 851 (21.4%) influenza B, and 54 (1.4%) influenza A and B positive specimens. Overall, 362/460 (78.7%) isolates from the SH seasons and 316/338 (93.5%) isolates from the NH seasons were matched to the SH and the NH vaccine strains, respectively (p < 0.001). Overall, 53.6% and 46.4% SH and NH vaccines, respectively, matched circulating strains in terms of vaccine strains and timing.Conclusion: In six years of surveillance in Kenya, influenza circulated at nearly equal levels during the SH and the NH influenza seasons. Circulating viruses Were matched to vaccine strains. The vaccine match decreased when both vaccine strains and timing were taken into consideration. Either vaccine formulation could be suitable for use in Kenya but the optimal timing for influenza vaccination needs to be determined. (C) 2016 Elsevier Ltd. All rights reserved.