Prospective associations between white matter hyperintensities and lower extremity function
Prospective associations between white matter hyperintensities and lower extremity function
复制标题
白质高信号与下肢功能之间的前瞻性关联
作者：
S. Moon;P. de Souto Barreto;Y. Rolland;M. Chupin;A. Bouyahia;L. Fillon;J. F. Mangin;S. Andrieu;M. Cesari;B. Vellas
目的评估约3年内无痴呆症且有记忆投诉的老年人的白色高信号（WMH）与下肢功能下降（LEF）的关系。方法我们从458名70岁或以上的社区居民中获得了基线时的脑MRI数据，并从358名成人中获得了平均963天的随访数据。我们使用短期物理性能电池（SPPB）评估LEF。我们使用混合效应线性回归将基线WMH体积和进展与SPPB评分随时间推移相关。对于次要分析，我们将基线WMH体积分为四分位数，并将WMH进展二分以比较快速和缓慢进展。结果在校正分析中，基线WMH体积（β = −0.017，95%置信区间[CI] −0.025至−0.009）以及WMH进展（β = −0.002，95% CI −0.003至−0.001）与SPPB性能下降显著相关。与基线WMH体积的最低四分位数相比，最高四分位数与SPPB性能下降相关（β = −0.301，95%CI −0.558至−0.044）。快速进展也与SPPB性能下降相关。我们在SPPB中发现了具有临床意义的差异，在24和36个月时，WMH进展缓慢的参与者得分较高。结论：基线水平和WMH进展与老年人SPPB表现的纵向下降相关。我们检测到SPPB性能比较WMH进展快与慢的临床意义的差异，表明WMH进展的速度是衰老过程中LEF的重要决定因素。
Objective To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints. Methods We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and from 358 adults over an average follow-up of 963 days. We evaluated LEF using the Short Physical Performance Battery (SPPB). We related baseline WMH volumes and progression to SPPB scores over time, using mixed-effect linear regressions. For the secondary analyses, we categorized baseline WMH volume into quartiles, and dichotomized the WMH progression to compare fast and slow progression. Results Baseline WMH volume (β = −0.017, 95% confidence interval [CI] −0.025 to −0.009), as well as WMH progression (β = −0.002, 95% CI −0.003 to −0.001), significantly associated with a decline in SPPB performance in adjusted analyses. Compared with the lowest quartile of baseline WMH volume, the highest quartile associated with a decline in SPPB performance (β = −0.301, 95% CI −0.558 to −0.044). Fast progression also associated with a decline in SPPB performance. We found clinically meaningful differences in the SPPB, with higher scores in participants with slow progression of WMH, at both 24 and 36 months. Conclusions Baseline level and WMH progression associated with longitudinal decline in SPPB performance among older adults. We detected clinically meaningful differences in SPPB performance on comparing fast with slow progression of WMH, suggesting that speed of WMH progression is an important determinant of LEF during aging.
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影响因子：
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作者：
B. Vellas;I. Carrié;S. Gillette‐Guyonnet;J. Touchon;T. Dantoine;J. Dartigues;M. Cuffi;S. Bordes;Y. Gasnier;P. Robert;L. Bories;O. Rouaud;F. Desclaux;K. Sudres;M. Bonnefoy;A. Pesce;C. Dufouil;S. Lehéricy;M. Chupin;J. F. Mangin;P. Payoux;D. Adel;P. Legrand;D. Catheline;C. Kanony;M. Zaim;L. Molinier;N. Costa;J. Delrieu;T. Voisin;C. Faisant;F. Lala;F. Nourhashemi;Y. Rolland;G. A. van Kan;C. Dupuy;C. Cantet;P. Cestac;S. Belleville;S. Willis;M. Cesari;M. Weiner;M. Soto;P. Ousset;S. Andrieu
通讯作者：
B. Vellas;I. Carrié;S. Gillette‐Guyonnet;J. Touchon;T. Dantoine;J. Dartigues;M. Cuffi;S. Bordes;Y. Gasnier;P. Robert;L. Bories;O. Rouaud;F. Desclaux;K. Sudres;M. Bonnefoy;A. Pesce;C. Dufouil;S. Lehéricy;M. Chupin;J. F. Mangin;P. Payoux;D. Adel;P. Legrand;D. Catheline;C. Kanony;M. Zaim;L. Molinier;N. Costa;J. Delrieu;T. Voisin;C. Faisant;F. Lala;F. Nourhashemi;Y. Rolland;G. A. van Kan;C. Dupuy;C. Cantet;P. Cestac;S. Belleville;S. Willis;M. Cesari;M. Weiner;M. Soto;P. Ousset;S. Andrieu
影响因子：
120.7
作者：
Pahor, Marco;Guralnik, Jack M.;Ambrosius, Walter T.;Blair, Steven;Bonds, Denise E.;Church, Timothy S.;Espeland, Mark A.;Fielding, Roger A.;Gill, Thomas M.;Groessl, Erik J.;King, Abby C.;Kritchevsky, Stephen B.;Manini, Todd M.;McDermott, Mary M.;Miller, Michael E.;Newman, Anne B.;Rejeski, W. Jack;Sink, Kaycee M.;Williamson, Jeff D.
通讯作者：
Williamson, Jeff D.
DOI：
10.1093/geronj/49.2.m85
发表时间：
1994-03-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
GURALNIK, JM;SIMONSICK, EM;WALLACE, RB
通讯作者：
WALLACE, RB
DOI：
10.1093/gerona/55.4.m221
发表时间：
2000-04-01
影响因子：
5.1
作者：
Guralnik, JM;Ferrucci, L;Wallace, RB
通讯作者：
Wallace, RB