Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans
Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans
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DOI：
10.3390/ijms20092214
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发表时间：
2019-05-01
影响因子：
5.6
通讯作者：
Hamaoka, Takafumi
中科院分区：
文献类型：
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作者：
Nirengi, Shinsuke;Fuse, Sayuri;Hamaoka, Takafumi
棕色脂肪组织（BAT）可能用于预防与生活方式有关的疾病。我们研究的证据表明，近红外时间分辨光谱（NIRTRS）是能够估计人体BAT密度（BAT-d）。本研究中检查的参数是总血红蛋白[total-Hb]（sup）、氧合血红蛋白[oxy-Hb]（sup）、脱氧血红蛋白[deoxy-Hb]（sup）、血红蛋白O-2饱和度（StO（2sup））和锁骨上区域的约化散射系数（（s '（sup）），BAT沉积物可位于锁骨上区域;在对照三角肌区域获得相应参数作为对照。在NIRTRS参数中，[total-Hb]（sup）和[oxy-Hb]（sup）在冬季表现出区域特异性增加，与夏季相比。此外，[total-Hb]（sup）和[oxy-Hb]（sup）与锁骨上区域的冷诱导产热相关。我们得出结论，NIRTRS测定的[总Hb]（sup）和[氧合Hb]（sup）是以简单、快速、无创的方式评价BAT-d的有用参数。
Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb](sup), oxygenated Hb [oxy-Hb](sup), deoxygenated Hb [deoxy-Hb](sup), Hb O-2 saturation (StO(2sup)), and the reduced scattering coefficient in the supraclavicular region ((s)'(sup)), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb](sup) and [oxy-Hb](sup) show region-specific increases in winter, compared to summer. Further, [total-Hb](sup) and [oxy-Hb](sup) are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb](sup) and [oxy-Hb](sup) are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner.