KERATIN-19 EXPRESSION IN THE ADULT AND DEVELOPING HUMAN MAMMARY-GLAND
KERATIN-19 EXPRESSION IN THE ADULT AND DEVELOPING HUMAN MAMMARY-GLAND
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DOI：
10.1007/bf01005976
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发表时间：
1990-10-01
期刊：
影响因子：
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通讯作者：
TAYLORPAPADIMITRIOU, J
中科院分区：
文献类型：
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作者：
BARTEK, J;BARTKOVA, J;TAYLORPAPADIMITRIOU, J
在成人乳腺中，大多数腔上皮细胞表达角蛋白19(K19+)。然而，在妊娠期间可能发生分支的一些小导管和末端导管小叶单位中，这种角蛋白的表达模式是异质性的。虽然角蛋白19阴性细胞(K19-)在体外和体内具有很高的增殖潜力，但它们的分泌活性低于K19+细胞，从静息乳腺的分泌成分或妊娠腺体中酪蛋白的表达来监测。K19-细胞在腔细胞谱系中形成一个独立的增殖室，这是因为它们在青春期前的乳房中不存在，只出现在青春期与分支导管和新形成的小叶相关的地方。我们的观察结果与以下假设一致，即K19-腔细胞的分化程度低于K19+腔细胞，并且可能是K19+腔细胞的前体，K19+腔细胞代表了能够对激素刺激产生乳汁的完全分化的表型。
In the adult human mammary gland, most of the luminal epithelial cells express keratin 19 (K19+). However, in some small ducts and terminal ductal lobular units where branching would be expected to occur during pregnancy, the pattern of expression of this keratin is-heterogeneous. While the keratin 19 negative cells (K19-) appear to have a high proliferative potential in vitro and in vivo, they have a lower secretory activity than the K19+ cells as monitored by expression of secretory component in the resting breast or casein in the pregnant gland. That the K19- cells form a separate proliferative compartment in the luminal cell lineage is suggested by the fact that they are absent in the prepubertal breast and only appear at puberty associated with branching ducts, and newly formed lobules. Our observations are consistent with the hypothesis that the K19- luminal cell is less differentiated than and may be precursor to the K19+ luminal cell, which represents the fully differentiated phenotype able to produce milk in response to a hormonal stimulus.