Apolipoprotein E and cognitive performance:: A meta-analysis
Apolipoprotein E and cognitive performance:: A meta-analysis
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DOI：
10.1037/0882-7974.19.4.592
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发表时间：
2004-12-01
影响因子：
3.7
通讯作者：
B채ckman, L
中科院分区：
文献类型：
--
作者：
Small, BJ;Rosnick, CB;B채ckman, L
载脂蛋白E（APOE）基因的ε 4等位基因是阿尔茨海默病的已知危险因素，也可能影响正常衰老的认知能力。通过对现有文献的荟萃分析，检查了ε 4相关认知缺陷的存在和程度的证据。共纳入38项研究，认知表现分为8个领域。结果表明，APOE-ε 4组在整体认知功能、情景记忆和执行功能方面存在显著差异，有利于非ε 4携带者。此外，年龄较大和APOE-ε 4杂合性与较小的ε 4相关损伤相关。荟萃分析结果表明，APOE-epsilon 4基因型确实影响健康老龄化的认知表现，尽管这种影响相对较小，并且仅限于认知表现的某些领域。
The epsilon4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's disease and may also affect cognitive performance in normal aging. Evidence of the presence and magnitude of epsilon4-related cognitive deficits was examined with a meta-analysis of the available literature. Thirty-eight studies were included, and cognitive performance was collapsed into 8 domains. Results indicated significant APOE-epsilon4 group differences for global cognitive functioning, episodic memory, and executive functioning, in favor of non-epsilon4 carriers. In addition, older age and APOE-epsilon4 heterozygosity was associated with smaller epsilon4-related impairments. The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance.