Amphiregulin from basophils amplifies basophil-mediated chronic skin inflammation
Amphiregulin from basophils amplifies basophil-mediated chronic skin inflammation
复制标题
来自嗜碱性粒细胞的双调蛋白放大嗜碱性粒细胞介导的慢性皮肤炎症
DOI：
10.1016/j.jid.2019.02.023
复制
发表时间：
2019
影响因子：
6.5
通讯作者：
Yokozeki Hiroo
中科院分区：
文献类型：
--
作者：
Hashimoto Takashi;Satoh Takahiro;Karasuyama Hajime;Yokozeki Hiroo
在慢性过敏性皮肤病如特应性皮炎（AD）和过敏性皮炎的病变中观察到大量嗜碱性粒细胞（Ito et al.，2011年）。有证据表明，嗜碱性粒细胞能够引起辅助性T细胞2型介导的炎症，因此，嗜碱性粒细胞被推断在慢性过敏性皮肤炎症中起关键作用（Karasuyama et al.，2018年）。然而，涉及嗜碱性粒细胞依赖性皮肤炎症的分子/介质尚未阐明。嗜碱性粒细胞依赖性慢性皮肤炎症模型之一的Alzigo反应的鼠模型的特征在于显著的嗜酸性粒细胞和嗜碱性粒细胞浸润以及增加的双调蛋白（AREG）（一种表皮生长因子样分子）的局部产生（Hashimoto等人，2015年）。AREG主要由上皮细胞产生，但该因子也由各种免疫细胞产生，包括嗜碱性粒细胞（Meulenbroeks et al.，2015，Qi等人，2010），并且与辅助性T细胞2型炎症有关（Zaiss et al.，2015年）。在这里，我们评估了嗜碱性粒细胞衍生的AREG在瘙痒样皮肤炎症和AD小鼠模型中的作用。所有动物实验均由东京医科和牙科大学的机构动物护理和使用委员会批准。
A large number of basophils are observed in the lesions of chronic allergic skin diseases such as atopic dermatitis (AD) and prurigo (Ito et al., 2011). Evidence suggests that basophils are capable of provoking T helper type 2-mediated inflammation, and thus, basophils are inferred to play a pivotal role in chronic allergic skin inflammation (Karasuyama et al., 2018). However, the molecules/mediators involved in basophil-dependent skin inflammation have yet to be elucidated.A murine model of prurigo reaction, one of the models of basophil-dependent chronic skin inflammation, features marked eosinophil and basophil infiltration and increased local production of amphiregulin (AREG), an epidermal growth factor-like molecule (Hashimoto et al., 2015). AREG is produced principally by epithelial cells, but the factor is also generated by various immune cells, including basophils (Meulenbroeks et al., 2015, Qi et al., 2010), and has been implicated in T helper type 2 inflammation (Zaiss et al., 2015). Here, we assessed the contribution of basophil-derived AREG in murine models of prurigo-like skin inflammation and AD. All animal experiments were approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University.