Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.
Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.
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DOI：
10.1111/acel.12475
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发表时间：
2016-06
期刊：
影响因子：
7.8
通讯作者：
Russell AJ
中科院分区：
文献类型：
--
作者：
Hinken AC;Powers JM;Luo G;Holt JA;Billin AN;Russell AJ
最近的高调研究报告GDF11是一个关键的循环“抗衰老”因子。然而，试图在老年小鼠骨骼肌卫星细胞中鉴定具有“抗衰老”表型的因子的细胞外蛋白筛选没有鉴定出GDF11活性。我们无法证实GDF11的活性，类似于其他实验室提供的相互矛盾的数据，并在此简短介绍我们的尝试。
Recent high‐profile studies report GDF11 to be a key circulating ‘anti‐aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti‐aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.