Prevalence and determinants of diabetic nephropathy in Korea: Korea national health and nutrition examination survey.
Prevalence and determinants of diabetic nephropathy in Korea: Korea national health and nutrition examination survey.
复制标题
韩国糖尿病性肾病的患病率和决定因素：韩国国家健康和营养检查调查。
DOI：
10.4093/dmj.2014.38.2.109
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发表时间：
2014-04
影响因子：
5.9
通讯作者：
Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association
中科院分区：
文献类型：
--
作者：
Ahn JH;Yu JH;Ko SH;Kwon HS;Kim DJ;Kim JH;Kim CS;Song KH;Won JC;Lim S;Choi SH;Han K;Cha BY;Kim NH;Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association
糖尿病肾病是终末期肾病的主要原因，与心血管死亡风险增加相关。它表现为蛋白尿或肾小球滤过率（GFR）受损，糖尿病肾病的患病率因种族而异。韩国成人糖尿病肾病的患病率及其决定因素以前没有在国家一级进行过研究。这项横断面研究旨在确定韩国糖尿病患者中蛋白尿和慢性肾脏病（CKD）的患病率和决定因素。2011年进行的韩国国家健康和营养检查调查（KNHANES）V用于定义白蛋白尿（n= 4，652），KNHANES IV-V（2008-2011）的数据集用于定义CKD（n= 21，521）。对选定的样本进行加权，以代表朝鲜的整个平民人口。白蛋白尿定义为点尿白蛋白/肌酐比值>30 mg/g。CKD定义为GFR <60 mL/min/1.73 m2。在糖尿病受试者中，26.7%有蛋白尿，8.6%有CKD。糖尿病与蛋白尿风险增加约2.5倍相关，新发和既往诊断的糖尿病之间几乎没有差异。在糖尿病患者中，只有收缩压与蛋白尿显著相关，而年龄、高血清甘油三酯水平和既往心血管疾病（CVD）与CKD相关。韩国糖尿病患者的蛋白尿和CKD患病率高于非糖尿病患者。在糖尿病患者中，血压与蛋白尿相关，年龄、甘油三酯水平和既往CVD是CKD的独立决定因素。
Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes. The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2. Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes. Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.