Molecular basis of Brucella pathogenicity: an update.
Molecular basis of Brucella pathogenicity: an update.
复制标题
布鲁氏菌致病性的分子基础：更新。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
J. Agüero
中科院分区：
文献类型：
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作者：
F. Sangari;J. Agüero
属于布鲁氏菌属的微生物可以感染人类和许多种动物。布鲁氏菌的毒力被认为主要是由于它们在吞噬细胞内生存和复制的能力。然而，在我们对布鲁氏菌逃避宿主吞噬细胞杀菌作用的能力的理解上仍然存在许多空白，基本的问题仍然没有得到回答。鉴定与细胞内生存相关的布鲁氏菌基因产物，以及那些有助于诱导保护性免疫的基因产物，对于阐明该生物发病的分子机制至关重要。本文综述了与布鲁氏菌毒力相关的基因产物和其他结构或代谢因子的研究现状。
Microorganisms belonging to the genus Brucella can infect humans and many species of animals. Virulence of the brucellae is thought to be essentially due to their capacity to survive and replicate within the phagocytic cells. However, many gaps remain in our understanding of this ability of brucellae to elude the bactericidal effects of host phagocytes, and basic questions remain unanswered. Identification of Brucella gene products which are related to intracellular survival, as well as those which contribute to the induction of protective immunity, is critical to elucidate the molecular mechanisms of the pathogenesis of the organism. The present article summarizes the current status of the research on gene products and other structural or metabolic factors associated with virulence of the brucellae.