A Magnetic-Field Guided Interface Coassembly Approach to Magnetic Mesoporous Silica Nanochains for Osteoclast-Targeted Inhibition and Heterogeneous Nanocatalysis
A Magnetic-Field Guided Interface Coassembly Approach to Magnetic Mesoporous Silica Nanochains for Osteoclast-Targeted Inhibition and Heterogeneous Nanocatalysis
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磁性介孔二氧化硅纳米链的磁场引导界面共组装方法，用于破骨细胞靶向抑制和多相纳米催化
DOI：
10.1002/adma.201707515
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发表时间：
2018
影响因子：
29.4
通讯作者：
Deng Yonghui
中科院分区：
文献类型：
--
作者：
Wan Li;Song Hongyuan;Chen Xiao;Zhang Yu;Yue Qin;Pan Panpan;Su Jiacan;Elzatahry Ahmed A.;Deng Yonghui
具有介孔结构的一维核壳磁性材料由于其独特的微观结构和形貌，在生物催化、磁性生物分离、生物富集和生物传感等领域具有重要的应用前景。在这项研究中，1D磁性介孔二氧化硅纳米链（Fe3O4@nSiO2@mSiO2nanochain，Magn-MSNCs命名为FDUcs-17 C）通过一种新的磁场引导界面共组装方法在两个步骤中容易地合成。在磁场中用无孔二氧化硅包覆Fe 3 O 4颗粒，形成一维Fe3O4@nSiO2纳米链。十六烷基三甲基溴化铵和二氧化硅源在水/正己烷双液体系中的进一步界面共组装导致具有核-壳-壳结构、均匀直径（约310 nm）、大且垂直的介孔（7.3 nm）、高表面积（317 m2 g-1）和高磁化强度（34.9 emu g-1）的1D Magn-MSNCs。在旋转磁场下，在介孔中负载唑来膦酸盐（一种用于治疗骨疾病的药物）的纳米链显示出有趣的破骨细胞分化抑制作用，这是由于它们的1D纳米结构在动态磁场中提供剪切力以诱导细胞中充分和有效的反应。此外，通过在介孔中负载Au纳米粒子，一维Fe3O4@nSiO2@mSiO2-Au纳米链可以作为一个具有催化活性的磁性纳米搅拌器，用于对硝基苯酚的加氢反应，具有较高的催化性能和良好的磁性可循环性.
1D core–shell magnetic materials with mesopores in shell are highly desired for biocatalysis, magnetic bioseparation, and bioenrichment and biosensing because of their unique microstructure and morphology. In this study, 1D magnetic mesoporous silica nanochains (Fe3O4@nSiO2@mSiO2nanochain, Magn‐MSNCs named as FDUcs‐17C) are facilely synthesized via a novel magnetic‐field‐guided interface coassembly approach in two steps. Fe3O4particles are coated with nonporous silica in a magnetic field to form 1D Fe3O4@nSiO2nanochains. A further interface coassembly of cetyltrimethylammonium bromide and silica source in water/n‐hexane biliquid system leads to 1D Magn‐MSNCs with core–shell–shell structure, uniform diameter (≈310 nm), large and perpendicular mesopores (7.3 nm), high surface area (317 m2g−1), and high magnetization (34.9 emu g−1). Under a rotating magnetic field, the nanochains with loaded zoledronate (a medication for treating bone diseases) in the mesopores, show an interesting suppression effect of osteoclasts differentiation, due to their 1D nanostructure that provides a shearing force in dynamic magnetic field to induce sufficient and effective reactions in cells. Moreover, by loading Au nanoparticles in the mesopores, the 1D Fe3O4@nSiO2@mSiO2‐Au nanochains can service as a catalytically active magnetic nanostirrer for hydrogenation of 4‐nitrophenol with high catalytic performance and good magnetic recyclability.