INVOLVEMENT OF CYCLIC-AMP AND ITS RECEPTOR PROTEIN IN FILAMENTATION OF AN ESCHERICHIA-COLI FIC MUTANT
INVOLVEMENT OF CYCLIC-AMP AND ITS RECEPTOR PROTEIN IN FILAMENTATION OF AN ESCHERICHIA-COLI FIC MUTANT
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DOI：
10.1128/jb.151.2.807-812.1982
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发表时间：
1982-01-01
影响因子：
3.2
通讯作者：
KOMANO, T
中科院分区：
文献类型：
--
作者：
UTSUMI, R;NAKAMOTO, Y;KOMANO, T
cAMP抑制E. coli PA 3092中进行诱导表达。这一现象首先在E. coliPA 3092中，由于温度敏感性突变。这种突变被命名为fic（cAMP诱导的突变）。fic基因位于E. coliK-12作图。cAMP对fic突变体细胞分裂和增殖的抑制作用在crp突变体中未观察到。当从培养基中除去cAMP时，随着细胞内cAMP水平降低，细丝被分成杆。cAMP-cAMP受体蛋白复合物在fic突变体E. coli PA3092。
cAMP inhibited septum formation in E. coli PA3092 and induced cell filamentation at elevated temperatures. This phenomenon was first observed in E. coli PA3092 and is due to a temperature-sensitive mutation. This mutation was named fic (filamentation induced by cAMP). The fic gene was located near rpsL (formerly strA) on the E. coli K-12 map. The inhibitory effect of cAMP on cell division and filamentation in a fic mutant was not observed in a crp mutant. When cAMP was removed from the culture medium, filaments were divided into rods as the intracellular cAMP level decreased. cAMP-cAMP receptor protein complex evidently causes filamentation in the fic mutant, E. coli PA3092.