Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation.
Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation.
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血管活性肠肽作为脑循环中的神经递质。
DOI：
10.1016/0014-2999(82)90041-3
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发表时间：
1982
影响因子：
5
通讯作者：
S. Said
中科院分区：
文献类型：
--
作者：
S. Duckles;S. Duckles;S. Said;S. Said
猫脑动脉表现出兔脑动脉所没有的非胆碱能神经源性血管扩张。放射免疫法测定的血管活性肠肽(VIP)水平与非胆碱能血管扩张相关：猫大脑前动脉为270±66pmol/g，兔脑动脉为10±2.3pmol/g。在没有内皮细胞的情况下，猫脑动脉不会对乙酰胆碱松弛，而是对神经刺激继续松弛。对VIP的放松反应也持续存在。这些发现与VIP在脑循环中介导非胆碱能血管扩张反应的可能性是一致的。
Cat cerebral arteries exhibit a non-cholinergic neurogenic vasodilation which is absent in rabbit cerebral arteries. Levels of vasoactive intestinal peptide (VIP) measured by radioimmunoassay are correlated with the presence of a non-cholinergic vasodilation: 270±66 pmol/g in the cat anterior cerebral artery compared to 10±2.3 pmol/g in rabbit cerebral arteries. In the absence of endothelial cells, cat cerebral arteries do not relax to acetylcholine, but continue to relax to nerve stimulation. Relaxation responses to VIP also persist. These findings are consistent with the possibility that VIP mediates non-cholinergic vasodilator responses in the cerebral circulation.
脑动脉功能性胆碱能神经支配的证据。
DOI：
--
发表时间：
1981
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Duckles,SP
通讯作者：
Duckles,SP