Cochlear nucleus lesions in the adult gerbil: effects on neurone responses in the contralateral inferior colliculus
Cochlear nucleus lesions in the adult gerbil: effects on neurone responses in the contralateral inferior colliculus
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DOI：
10.1016/0006-8993(86)90341-0
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发表时间：
1986-05
期刊：
影响因子：
2.9
通讯作者：
D. Moore;L. Kitzes
中科院分区：
文献类型：
--
作者：
D. Moore;L. Kitzes
新生沙土鼠单侧耳蜗术后，其腹侧耳蜗核(CN)发生跨神经元变性，对侧下丘(IC)对未消融耳的刺激反应增强。这两种影响都不会发生在成年消融动物身上。为了确定成年沙土鼠缺乏生理变化是否是由于腹侧CN的持续存在，我们损毁了成年沙土鼠的左侧CN，并记录了右侧IC对刺激右耳的神经元反应。神经元阈值、潜伏期和强度/反应功能不受损害的影响。在IC中获得兴奋反应的记录位点的比例也不受影响。在最大单位流量水平上观察到了暂时性的增加。这些发现表明，成人的CN损害不会产生新生儿耳蜗术后引起的神经元变化的范围和程度，也不会导致CN的跨神经元变性。因此，耳蜗术的效果是年龄相关的。
Unilateral cochlea ablation in neonatal gerbils has previously been shown to result in transneuronal degeneration of the ventral cochlear nucleus (CN) and enhanced responses in the contralateral inferior colliculus (IC) to ipsilateral stimulation of the non-ablated ear. Neither effect occurs in adult-ablated animals. To determine whether the lack of physiological change in the adult is due to the persistence of the ventral CN we lesioned the left CN of adult gerbils and recorded neurone responses in the right IC to stimulation of the right ear. Neurone thresholds, latency and intensity/response functions were unaffected by the lesion. The proportion of recording loci in the IC at which excitatory responses were obtained was also unaffected. A transient increase was obserbed in the maximum unit discharge level. The findings suggest that CN lesions in adults do not produce either the range or degree of neuronal changes resulting from neonatal cochlea ablation and the subsequent transneuronal degeneration of the CN. Thus, the effects of cochlea ablation are age-dependent.