Aerobic Interval Training Reduces the Burden of Atrial Fibrillation in the Short Term A Randomized Trial
Aerobic Interval Training Reduces the Burden of Atrial Fibrillation in the Short Term A Randomized Trial
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DOI：
10.1161/circulationaha.115.018220
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发表时间：
2016-02-02
期刊：
影响因子：
37.8
通讯作者：
Loennechen, Jan P.
中科院分区：
文献类型：
--
作者：
Malmo, Vegard;Nes, Bjarne M.;Loennechen, Jan P.
运动训练是治疗心房颤动（AF）重要合并症的有效方法。然而，高水平的耐力运动与房颤患病率增加有关。我们评估了有氧间歇训练（AIT）对房颤患者的时间、房颤症状、心血管健康和生活质量的影响。方法和结果51例非永久性房颤患者随机分为四组（n=26），每周三次，每次4分钟，心率为峰值的85%至95%，持续12周；对照组（n=25）继续他们的常规运动习惯。植入的环路记录仪从干预期前4周至干预期后4周连续测量AF时间。在12周干预期前后评估心功能、峰值摄氧量、血脂状态、生活质量和房颤症状。对照组的平均房颤时间从10.4%增加到14.6%，运动组从8.1%减少到4.8%（组间P=0.001）。AF症状频率（P=0.006）和AF症状严重程度（P=0.009）均明显降低。与对照组相比，AIT改善了左心房和心室射血分数、总体健康和活力的生活质量指标以及血脂值。在AIT后，心脏复律和住院次数有减少的趋势。结论：非永久性房颤患者进行12周AIT治疗可缩短房颤时间，随后房颤症状、o(2)峰、左心房和心室功能、脂质水平和生活质量均有显著改善。临床试验注册网址：http://www.clinicaltrials.gov。唯一标识符：NCT01325675。
Background Exercise training is an effective treatment for important atrial fibrillation (AF) comorbidities. However, a high level of endurance exercise is associated with an increased AF prevalence. We assessed the effects of aerobic interval training (AIT) on time in AF, AF symptoms, cardiovascular health, and quality of life in AF patients.Methods and Results Fifty-one patients with nonpermanent AF were randomized to AIT (n=26) consisting of four 4-minute intervals at 85% to 95% of peak heart rate 3 times a week for 12 weeks or to a control group (n=25) continuing their regular exercise habits. An implanted loop recorder measured time in AF continuously from 4 weeks before to 4 weeks after the intervention period. Cardiac function, peak oxygen uptake , lipid status, quality of life, and AF symptoms were evaluated before and after the 12-week intervention period. Mean time in AF increased from 10.4% to 14.6% in the control group and was reduced from 8.1% to 4.8% in the exercise group (P=0.001 between groups). AF symptom frequency (P=0.006) and AF symptom severity (P=0.009) were reduced after AIT. AIT improved , left atrial and ventricular ejection fraction, quality-of-life measures of general health and vitality, and lipid values compared with the control group. There was a trend toward fewer cardioversions and hospital admissions after AIT.Conclusions AIT for 12 weeks reduces the time in AF in patients with nonpermanent AF. This is followed by a significant improvement in AF symptoms, o(2)peak, left atrial and ventricular function, lipid levels, and QoL.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01325675.