IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure
IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure
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DOI：
10.1161/circheartfailure.118.005133
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发表时间：
2018-10-01
影响因子：
9.7
通讯作者：
Solomon, Scott D.
中科院分区：
文献类型：
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作者：
Januzzi, James L., Jr.;Packer, Milton;Solomon, Scott D.
背景技术背景：IGFBP 7（胰岛素样生长因子结合蛋白-7）的活性增加与细胞衰老，组织衰老和肥胖有关。IGFBP 7可能与心脏衰竭与保留射血分数，老年肥胖people.METHODS和结果：在一个子集的心脏衰竭与保留射血分数（N=228）随机接受沙库巴曲/缬沙坦与缬沙坦，IGFBP 7浓度测定在基线，12周和36周。评估患者特征和超声心动图测量，包括左心房（LA）大小和体积，早期二尖瓣流入速度/瓣环舒张速度的比值，以及早期二尖瓣/舒张晚期峰值速度的比值作为IGFBP 7浓度的函数。分析沙库巴曲/缬沙坦对IGFBP 7浓度的影响。随着基线IGFBP 7四分位数的增加，LA大小和LA体积指数（LAVi）在所有时间点均升高（均P= 34 mL/m2），而LAVi在所有时间点均降低（均P
BACKGROUND: Increased activity of IGFBP7 (insulin-like growth factor-binding protein-7) is associated with cellular senescence, tissue aging, and obesity. IGFBP7 may be related to heart failure with preserved ejection fraction, a disease of elderly obese people.METHODS AND RESULTS: In a subset of patients with heart failure with preserved ejection fraction (N=228) randomized to receive sacubitril/valsartan versus valsartan, IGFBP7 concentrations were measured at baseline, 12 weeks, and 36 weeks. Patient characteristics and echocardiographic measures including left atrial (LA) size and volume, ratio of early mitral inflow velocity/annular diastolic velocity, and ratio of early diastole/peak late diastolic velocity were assessed as a function of IGFBP7 concentration. Effect of sacubitril/valsartan on IGFBP7 concentrations was analyzed. With increasing baseline IGFBP7 quartiles, LA size and LA volume index (LAVi) were higher (both P= 34 mL/m(2) compared with lower LAVi at all time points (all P