Localization of c-ras oncogene family on human germ-line chromosomes.
Localization of c-ras oncogene family on human germ-line chromosomes.
复制标题
c-ras癌基因家族在人类种系染色体上的定位。
DOI：
10.1073/pnas.80.15.4794
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发表时间：
1983
影响因子：
11.1
通讯作者：
Chaganti,RS
中科院分区：
文献类型：
--
作者：
Jhanwar,SC;Neel,BG;Hayward,WS;Chaganti,RS
c-ras家族是一组在脊椎动物中高度保守的c-onc基因。该家族中的基因与Harvey和Kirsten鼠肉瘤病毒的转化基因（分别为v-Ha-ras和v-Ki-ras）同源。使用原位分子杂交方法，我们检测到三个网站上的人类粗线期染色体表现出显着的杂交v-Ki-ras和v-Ha-ras探针。这些是与体细胞染色体11p14.1、12p12.1和12q24.2带相对应的染色粒位置。这些染色体位点和以前定义的人类c-ras基因家族成员之间的关系进行了讨论。已知这些染色体位点参与多种肿瘤和几种易患肿瘤性疾病的先天性疾病中的特定染色体变化。
The c-ras family is a set of c-onc genes that are highly conserved in vertebrates. The genes in this family are homologous to the transforming genes of Harvey and Kirsten murine sarcoma viruses (v-Ha-ras and v-Ki-ras, respectively). Using an in situ molecular hybridization method, we detected three sites on the human pachytene chromosomes that exhibited significant hybridization to v-Ki-ras and v-Ha-ras probes. These were chromomere positions that corresponded to bands 11p14.1, 12p12.1, and 12q24.2 of somatic chromosomes. The relationship between these chromosomal sites and previously defined members of the human c-ras gene family is discussed. These chromosomal sites are known to be involved in specific chromosome changes in a variety of tumors and in several congenital disorders that predispose to neoplastic disease.