Unique associations between HLA-B and HLA-DRB1*04 gene variants in Japanese.
Unique associations between HLA-B and HLA-DRB1*04 gene variants in Japanese.
复制标题
日语中 HLA-B 和 HLA-DRB1*04 基因变异之间的独特关联。
DOI：
10.1111/j.1399-0039.1993.tb02194.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
H. Maeda
中科院分区：
文献类型：
--
作者：
T. Nishimoto;K. Matsuki;S. Islam;R. Hirata;H. Maeda
采用PCR-SSCP和PCR-RFLP检测明显健康的日本人HLA-DRB1*04基因变异，统计估计HLA-B-DRB1*04单倍型频率。DRB1*0405占日本DRB1*04基因库的60%，与HLA-B54有较强的相关性。这种关联仅在DRB1*0405中观察到，而在任何其他DR4变体中都没有观察到。DRB1*0403和DRB1*0406均与B35和B62相关，除了第37个氨基酸外，它们具有相同的肽序列。DRB1*0407仅与B35相关。DRB1*0410与B60、B61相关。而B60和B61仅与DRB1*0410和DRB1*0405相关。B35与所有DR4微变异相关。除了这个可能的例外，我们的计算表明，即使在DR4微变异中，也存在独特的B-DR关联。HLA-B和DRB1*04相关性的知识在临床环境中是有用的。
HLA-DRB1*04 gene variants were determined in apparently healthy Japanese with PCR-SSCP and PCR-RFLP, and HLA-B-DRB1*04 haplotype frequencies were estimated statistically. DRB1*0405, which consisted of 60% of the Japanese DRB1*04 gene pool, was associated strongly with HLA-B54. This association was observed only for DRB1*0405, and not for any other DR4 variants. DRB1*0403 and DRB1*0406, which share the same peptide sequence except for amino acid 37, were both associated with B35 and B62. DRB1*0407 was associated exclusively with B35. DRB1*0410 was associated with B60 and B61. B60 and B61, on the other hand, were associated only with DRB1*0410 and DRB1*0405. B35 was associated with all DR4 microvariants. With this possible exception, our calculation suggests that unique B-DR associations were present even for DR4 microvariants. The knowledge of HLA-B and DRB1*04 associations would be useful in clinical settings.