Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia.
Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia.
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人胰岛素受体基因：定位于 19 号染色体上与前 B 细胞白血病有关的位点。
DOI：
10.1126/science.3873110
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Ullrich,A
中科院分区：
文献类型：
--
作者：
Yang-Feng,TL;Francke,U;Ullrich,A
肿瘤细胞中持续的染色体易位可能改变位于断裂点附近的原癌基因的表达。人胰岛素受体的互补DNA序列与EGF受体（erbBoncogene）和癌基因src家族产物的互补DNA序列相似。通过体细胞杂交DNA的原位杂交和Southern印迹分析，将人胰岛素受体基因定位于19号染色体的远端短臂（p13.2→p13.3带），这是前B细胞急性白血病中参与非随机易位的位点。
Consistent chromosomal translocations in neoplastic cells may alter the expression of proto-oncogenes that are located near the breakpoints. The complementary DNA sequence of the human insulin receptor is similar to those of the EGF receptor (erbBoncogene) and products of the src family of oncogenes. With in situ hybridization and Southern blot analysis of somatic cell hybrid DNA, the human insulin receptor gene was mapped to the distal short arm of chromosome 19 (bands p13.2→p13.3), a site involved in a nonrandom translocation in pre-B-cell acute leukemia.