Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock
Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock
复制标题
DOI：
10.1016/j.celrep.2021.109336
复制
发表时间：
2021-07-06
期刊：
影响因子：
8.8
通讯作者：
Shibata, Shigenobu
中科院分区：
文献类型：
--
作者：
Aoyama, Shinya;Kim, Hyeon-Ki;Shibata, Shigenobu
一天中蛋白质的膳食分布通常是偏斜的。然而，其生理意义和更好的蛋白质分布对肌肉体积的影响在很大程度上是未知的。在这里，使用每天两餐的喂养模型，我们发现，蛋白质摄入量在早期活动阶段促进超负荷诱导的肌肉肥大，在一种依赖于当地的肌肉时钟。在早期活动阶段喂食补充支链氨基酸（BCAA）的饮食的小鼠表现出骨骼肌肥大。然而，在Clock（Delta 19）或肌肉特异性Bmal 1敲除小鼠中没有观察到分布依赖性效应。此外，我们还研究了膳食中蛋白质的分布与肌肉功能之间的关系，例如人类的骨骼肌指数和握力。在主要在早餐摄入膳食蛋白质的受试者中观察到的肌肉功能高于晚餐。这些数据表明，早餐时摄入蛋白质可能更有利于维持骨骼肌质量。
The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the effects of better protein distribution on muscle volume are largely unknown. Here, using the two-meals-per-day feeding model, we find that protein intake at the early active phase promotes overloading-induced muscle hypertrophy, in amanner dependent on the local muscle clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets at the early active phase demonstrate skeletal muscle hypertrophy. However, distribution-dependent effects are not observed in Clock(Delta 19) or muscle-specific Bmal1 knockout mice. Additionally, we examined the relationship between the distribution of proteins in meals and muscle functions, such as skeletal muscle index and grip strength in humans. Higher muscle functions were observed in subjects who ingested dietary proteins mainly at breakfast than at dinner. These data suggest that protein intake at breakfast may be better for the maintenance of skeletal muscle mass.