New regiocontrolled synthesis of functionalized pyrroles from 2-azetidinone-tethered allenols
New regiocontrolled synthesis of functionalized pyrroles from 2-azetidinone-tethered allenols
复制标题
DOI：
10.1002/chem.200700788
复制
发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Redondo, Maria C.
中科院分区：
文献类型：
--
作者：
Alcaide, Benito;Almendros, Pedro;Redondo, Maria C.
开发了一种新的一锅法，可以从 β-内酰胺合成密集取代的外消旋和对映体纯吡咯。该方法依赖于 2-氮杂环丁酮束缚的二烯醇开环衍生的 β-丙二烯胺中间体的区域控制环化。在该方法中引入了四个多样性点，其中之一是β-内酰胺环上丙二烯部分的位置。
A new one-pot approach to synthesize densely substituted racemic and enantiopure pyrroles from beta-lactams has been developed. The approach relies on the regiocontrolled cyclization of beta-allenamine intermediates derived from the ring opening of 2-azetidinone-tethered allenols. In this approach four points of diversity are introduced, one of which is the position of the allene moiety on the beta- lactam ring.