3D BOLUS TRACKING WITH FREQUENCY-SHIFTED BURST MRI
3D BOLUS TRACKING WITH FREQUENCY-SHIFTED BURST MRI
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DOI：
10.1097/00004728-199409000-00002
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发表时间：
1994-09-01
影响因子：
1.3
通讯作者：
MOONEN, CTW
中科院分区：
文献类型：
--
作者：
DUYN, JH;VANGELDEREN, P;MOONEN, CTW
目的：我们的目标是开发和测试一个3D团注跟踪MR技术正常和病理（梗死）人脑perfusion imaging。材料和方法：所有实验进行标准的1.5 T GE/Signa临床扫描仪。研究了5名正常志愿者和1名亚急性脑梗死患者。在肘前静脉注射Gd-DTPA（0.13 mmol/kg）期间进行改良[频移（FS）] BURST MRI。采集的3D数据集的时间分辨率为2.2 s，有效空间分辨率为4.3 x 4.3 x 6.4 mm。血容量和团注到达时间的三维图通过将合成曲线拟合到逐体素的强度时间过程来确定。结果：相对脑血容量和到达时间图均显示出对正常脑和亚急性脑梗死血供区域差异的敏感性。通过时间图显示到达时间延迟5-7秒内和周围的梗死，并确认诊断左大脑中动脉occlusion.Conclusion：正常和患病的人脑的测量结果表明，有能力获得有价值的三维信息，脑灌注使用FS BURST MRI。
Objective: Our goal was to develop and test a 3D bolus-tracking MR technique for perfusion imaging of normal and pathological (infarcted) human brain.Materials and Methods: All experiments were performed on standard 1.5 T GE/Signa clinical scanners. Five normal volunteers and one patient with a subacute brain infarct were studied. Modified [frequency-shifted (FS)] BURST MRI was performed during injection of a bolus of Gd-DTPA (0.13 mmol/kg) in the antecubital vein. The 3D datasets were acquired with a time resolution of 2.2 s and an effective spatial resolution of 4.3 x 4.3 x 6.4 mm. Three-diemensional maps of blood volume and bolus arrival time were determined by fitting a synthetic curve to the intensity time course on a voxel-by-voxel basis.Results: Both relative cerebral blood volume and arrival time maps demonstrated sensitivity to regional differences in blood supply in both normal brain and in the subacute brain infarction. The transit time maps showed arrival time delays of 5-7 s within and around the infarct and confirmed the diagnosis of left middle cerebral artery occlusion.Conclusion: The results of the measurements on both normal and diseased human brain demonstrated the ability to acquire valuable 3D information about brain perfusion using FS BURST MRI.