Basophil activation test in food allergy: is it ready for real-time?
Basophil activation test in food allergy: is it ready for real-time?
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DOI：
10.1097/aci.0000000000000774
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发表时间：
2021-10-01
影响因子：
2.8
通讯作者：
Patil SU
中科院分区：
文献类型：
--
作者：
Keswani T;Patil SU
嗜碱性细胞活化在食物过敏诊断和监测中的应用已得到越来越多的重视。作为一种体外功能分析，嗜碱性细胞的激活反映了临床的反应性，从而提供了临床相关的见解。此外，作为反应性和耐受性的生物标志物，嗜碱性细胞激活试验(BAT)可能为食物过敏的管理提供有用的工具。尽管BAT很有用，但它的显著局限性阻碍了它的广泛使用。解决这些限制将增加未来BAT在食物过敏中的应用和采用。过去几年的一些临床试验证明，BAT在食物过敏的诊断和治疗中使用。具体地说，BAT被发现是耐受性的生物标志物。嗜碱性细胞活化试验是诊断和监测食物过敏的有效生物标志物。
Utilization of basophil activation in the diagnosis and monitoring of food allergy has gained increasing recognition. An ex vivo functional assay, basophil activation reflects clinical reactivity, thereby providing clinically relevant insights. Moreover, as a biomarker of reactivity and tolerance, basophil activation testing (BAT) may provide a useful tool for management of food allergies. Despite its utility, significant limitations of BAT have prevented widespread use. Addressing these limitations will increase the future application and adoption of BAT in food allergy. A number of clinical trials in the past few years have demonstrated the use of BAT in the diagnosis and treatment of food allergy. Specifically, BAT has been found to be a biomarker of tolerance. Basophil activation testing is an effective biomarker for diagnosis and monitoring of food allergy.